seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
During the last three days, I've done 20+ hours of labor renovating / remodeling my house! Ripped up tons of carpet, nailing down a subfloor, moving heavy furniture and other stuff. I'm sore, but this is the best I've been in 3 years!! I have driven somewhere the last 10 days. I did have some episodes, but a 200% improvement in stamina from before.
keeping my fingers crossed!!! As of Apr-10, I've been on some form of Abx for 18 months now. Not what they should've been, poor protocols, not Dr. B aggressive, but something.
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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kidsgotlyme
Frequent Contributor (1K+ posts)
Member # 23691
posted
That's wonderful news!!! So happy for you.
-------------------- symptoms since 1993 that I can remember. 9/2018 diagnosed with Borellia, Babesia Duncani, and Bartonella Hensalae thru DNA Connections. Posts: 1470 | From Tennessee | Registered: Dec 2009
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D Bergy
Frequent Contributor (1K+ posts)
Member # 9984
posted
Congratulations.
It must be working for you, so stick with it.
Dan
Posts: 2919 | From Minnesota | Registered: Aug 2006
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feelfit
Frequent Contributor (1K+ posts)
Member # 12770
posted
!!!!! [hands together] Great Seek!
Posts: 3975 | From usa | Registered: Aug 2007
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-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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sutherngrl
Frequent Contributor (1K+ posts)
Member # 16270
posted
That sounds very encouraging Seek!
I just had a busy weekend, doing much more than I usually do and so far I'm hanging in there better than usual.
Maybe our turning point is here! I've always said, its more about time, than dosage, and I do believe that!
Posts: 4035 | From Mississippi | Registered: Jul 2008
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seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Thanks everyone. You may not believe this, but I truly believe a big factor was removal of a blood pressure medication I was on for 7+ years. An ULTRASOUND TECH, not any of the 40+ docs I saw - including a famous LLMD, came up with or remotely considered this idea. He suffered terribly for 1+ years and wound up in the ER with shortness of breath, fatigue, etc. over a year period.
I of course ran it by my doctor. He OKed this idea and we're exploring other options.
Of course I believe I have TBIs and am not off Biaxin. I don't think my 3-day course of Malarone knocked out WA-1. lol.
Maybe GiGi is right. It's never 'just Lyme.' Also, the weather change has helped as it does for many. I suffer horribly in Winter and very cold days (and will probably in very hot days).
I'll take what I can get and appreciate anything. I know this is a long route and I'm far from normal as my body hurts badly from doing anything. I had several times where I was breaking out in cold sweats last week. Not normal at all. I think Babesia is here.
quote:Originally posted by Lymetoo: ARE YOU KIDDING ME!!!!????
Oh my word!!!
Any recent changes to your regimen that has made the difference???
Hey.. I kept telling you to hang in there!!!! WOOOOHOOOO!!!!
[ 04-12-2010, 12:54 AM: Message edited by: seekhelp ]
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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posted
Out of curiosity, what blood pressure med were you taking?
Posts: 584 | From NY | Registered: Feb 2009
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seekhelp
Frequent Contributor (5K+ posts)
Member # 15067
posted
Norvasc and Lisinopril. Completely stopped the Norvasc, 1/2 dosed Lisinopril.
Posts: 7545 | From The 5th Dimension - The Twilight Zone | Registered: Mar 2008
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posted
Norvasc is a calcium channel blocker, isn't it? I recall reading a lot of negative things about them.
There are some supplements you can talk to your doctor about for BP reduction, in lieu of meds (in case lisinopril isn't enough): magnesium, pomegranate, CoQ10/Ubiquinol, fish oil, lycomato, pycnogenol and grapeseed extract (meganatural BP).
I'm not suggesting all of them, as I doubt you want your BP dropping too much, but if you still are sort of borderline hypertensive, a couple of those may help.
Posts: 584 | From NY | Registered: Feb 2009
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posted
Great News! So happy for you. I think once you get a handle on the Babs, you will feel that you have even more energy.
Posts: 379 | From Sydney, Australia | Registered: Nov 2008
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littlebit27
Frequent Contributor (1K+ posts)
Member # 24477
posted
That is awesome! You give other people hope they will one day feel better!
Jane2904
Frequent Contributor (1K+ posts)
Member # 15917
posted
Wonderful news, I am so happy for you!!
Posts: 1357 | From Massachusetts | Registered: Jun 2008
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dmc
Frequent Contributor (1K+ posts)
Member # 5102
posted
Wonderful but this thread belongs in "general"
Posts: 2675 | From ct, usa | Registered: Jan 2004
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cactus
Frequent Contributor (1K+ posts)
Member # 7347
posted
Woo hoo! Great news!!!!
Didn't you just finish some babs treatment recently? Think that helped?
Enjoy it!
-------------------- �Did you ever stop to think, and forget to start again?� - A.A. Milne Posts: 1987 | From No. VA | Registered: May 2005
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Bugg
Frequent Contributor (1K+ posts)
Member # 8095
posted
Seek-
I'm so happy for you. Wonderful news. You, like I, have suffered a lot from fatigue and lack of stamina/pain in the legs. I really believe that keeping the right BALANCE of minerals/vitamins in our system for muscles is important (amino acids, calcium, vitamin d, magnesium).
As you may be aware, calcium blockers can interact with some of the aformentioned. Anyway, I thought you might be interested in some user comments I found regarding Norvasc:
joalo
Frequent Contributor (1K+ posts)
Member # 12752
posted
Thanks for sharing your awesome news!!
-------------------- Sick since January 1985. Misdiagnosed for 20 years. Tested CDC positive October 2005. Treating since April 2006. Posts: 3228 | From Somewhere west of the Mississippi | Registered: Aug 2007
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posted
Norvasc was a terrible drug for my mother too. Mainly made her cough 24/7.
Have you tried terazosin for BP?
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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sammy
Frequent Contributor (5K+ posts)
Member # 13952
posted
Congratulations Seek! I'm so happy to hear that you are feeling better Posts: 5237 | From here | Registered: Nov 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I am happy to hear you are feeling better. Can you come to Florida and help me with a few chores? ;-)
Since I seldom read general, I'm glad you posted your information here because it triggered some additional research today (which is a lot more fun than vaccuming).
Anyway...
Calcium stimulates glucose uptake (*in muscles*)! (This may account for your increased endurance.)
P13K = phosphatidylinositol 3-kinase which is linked to lots of functions including
cell survival.
PI3K-C2beta to increases TCR-stimulated (T cell receptor) activation of KCa3.1 and
***Ca(2+) influx to activate the T-cells.***
P13K - C2alpha looks to activate glucokinase the first enzyme needed for glycolysis to happen.
So can you see with those 2 P13Ks...the defense cell is primed to receive glucose.
This is very tricky because Bb needs glucose, but so do we. There is one exception...WE can use ketones to make OUR ATP.
On the internet there are pictures of how Biaxin works. It involves arginine. L-arginine is a ***substrate (one of 3) for the pertussis "toxin"*** which looks to be very very similar to what Bb's "toxin" does.
That toxin inactivates Gi because all of the substrates make up Gi! The infected cell sends to the surface a receptor...GPR 109A which is a
nicotinic acid receptor.
Like the CB2 receptors (to stop inflammation), the GRP109A receptor maybe also a call for help.
On way from pyruvate to lactate (fermenting glucose to pyruvate to lactate)...nicotinamide is broken down by nicotinamidase:
which does this:
nicotinamide + H2O <-> nicotinate + NH3
Notice it goes both ways.
NH3 is ammonia which is very toxic.
Nicotinate is a salt or ester of nicotinic acid and it is a peripheral vasodilator and cholesterol depressant.
With Gi inhibited (nothing to make it - Bb is using all the nutrients) the infected cells are stuck with GDP (not going to GTP), elevated cAMP, lots of PPi. The Na-Ca channel is open.
Mitochondria can't produce enough ATP to rescue the cell.
Bb ferments glucose -> pyruvate -> lactate.
Normally (without Bb present) pyruvate goes into the mitochondria where it -> acetyl CoA -> the TCA/citric acid cycle/Krebs cycle -> a lot more ATP.
(Can you see how Bb thus "steals" energy nutrients from the cells it infects?)
If we can get ATP up, it can donate a phosphate to GDP -> GTP -> close the Na-Ca channel "doors".
In the presence of TNFa and IL6 our liver can't convert caprylic acid to make a ketone called BHB which could "rescue" the infected defense cell and theoretically destroy Bb in the process.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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CherylSue
Frequent Contributor (1K+ posts)
Member # 13077
posted
Hey, Seek, I'm so glad to hear the good news. I know you suffered a lot like me, and I've been working full time for the last year and a half.
Are you still seeing Dr.C? I didn't start to feel better until I was on abx for about 22 months, so that's the key. Keep up the good work!
CherylSue
Posts: 1954 | From Illinois | Registered: Aug 2007
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