LymeNet Flash: Young age a predictor of weak reactivity in a rapid antibody test in infants infected

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Young age a predictor of weak reactivity in a rapid antibody test in infants infected

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Topic: Young age a predictor of weak reactivity in a rapid antibody test in infants infected

Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

posted

http://www.ncbi.nlm.nih.gov/pubmed/20572089 2010 Aug
In a resource-constrained African setting, children suspected of being
infected with HIV are often screened with rapid antibody tests prior to
definitive diagnosis with viral genome detection.
It has previously been
... shown that a rapid antibody assay such as the Capillus HIV-1/HIV-2 test
may have a high false-negative rate in infants.
In this study CD(4) (+)
count and percentage, HIV-1 viral load, antigen-specific reactivity,
and age was explored as predictors of negative or low antibody
reactivity by this assay.
Young age was found to be the only factor
associated significantly with low antibody reactivity. --------------------------------

This phenomenon
appeared to be specific to HIV since no such age association was found
for antibody reactivity to tetanus toxoid.

Rapid assays only validated
in adults should therefore be used with utmost caution in young infants
since this may lead to high rates of false-negative results.
==============================
They should seriously be considering the stealth of Borrelia.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008 | IP: Logged |

Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

posted

IMO---They should "Stand Down".

Until these patients can be thoroughly

investigated by researchers like Dr. Sapi who know

how to find these in the biofilms that hide them...

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008 | IP: Logged |

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