Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
(Watch for ***)
The following explains why the higher EPA to DHA (like that in OmegaBrite) is important from Dr. Andrew Stoll, director of the Psychopharmacology Research Laboratory at Harvard Medical School-McLean Hospital :
``Dr. Stoll: No one has replicated the findings of our original study as yet. The real story now is that there are now numerous positive studies on the benefits of omega-3 in unipolar depression, schizophrenia, borderline personality disorder, ADHD, and Huntington's disease.
It seems that many disorders respond to omega-3s. Three of the four studies in depression used EPA, or EPA plus DHA, and they worked.
The fourth study used pure DHA--important for developing babies, pregnant women, and nursing mothers--and it failed.
***People hold onto stores of DHA for a long time, so you don't need to replenish levels as often as with EPA, which is turned over constantly, by conversion into eicosanoid hormones.'' ***
Lower quality supplements:
``Dr. Stoll: There isn't. Some people may experience GI distress if they take a large amount of a low-quality supplement.
But the highest good-quality fish oil is not rancid and
has little or no taste and has no side effects.
Another issue that people worry about is bleeding, because EPA inhibits platelet aggregation. But we scoured the scientific literature, and there has never been a documented case of bleeding due to omega-3 fatty acids.''
``Dr. Stoll: This remains an unresolved issue, but I like a 7:1 ratio of EPA to DHA. That high ratio delivers plenty of EPA--the presumed active ingredient--and also provides an adequate amount of DHA. More DHA is required during pregnancy or while nursing to replenish stores.
Most adults and children seem to have adequate or nearly adequate stores of DHA in their brains. Believe it or not, these DHA stores in the membranes of brain cells date back to a person's fetal life and is provided by their mothers.
***DHA turns over very slowly, so you don't need much to get by. In contrast, EPA is turned over very rapidly, as it is used for eicosanoid synthesis. For this reason, we think people are also much more depleted in EPA than DHA.''***
The results suggest that 22:4(n-6) = adrenic acid and to some extent 22:6(n-3) = DHA are
oxidized by peroxisomal beta-oxidation and by this are ***retroconverted to arachidonic acid and eicosapentaenoic acid.***
PMID: 2935195
Looks like Bb doesn't have a PKC inhibitor...we provide it!
the omega-3 fatty acid eicosapentaenoic acid (EPA), which ***inhibits PKC beta II activity***
and colon carcinogenesis, causes inhibition of Cox-2 protein expression, re-expression of TGF-beta RII, and restoration of TGF-beta1-mediated transcription in RIE/PKC beta II cells.
PMID: 12480928
(Me...inhibiting COX2 is a good thing...ouch wise.)
These data demonstrate for the first time that dietary ***DHA***alters T cell membrane microdomain composition and ***suppresses the PKC (theta symbol) signaling axis.***
PKC theta (circle with a horizontal line in it) apparently is anti-apoptotic (prevents cell death). DHA, if not oxidized thus might -> cell death.
There is a delicate balance going on...infected DNA damaged cells need to die, but slowly because if too many die too fast = sepsis = death. The pathway that is triggered is called P13K.
But...does this destroy Bb (when the infected cells are knocked off) and/or then make it easier for abx. to reach and destroy Bb?
"Today's featured study from Lilly reports that ***PKC theta-deficient*** mice were completely resistant to the development of clinical experimental
autoimmune encephalomyelitis
compared with wild-type control mice."
J Biol Chem.2004 Nov 26;279(48):50401-9
On the flip side, we might be able to "rescue" our infected defense cells by supplying them with BHB (a ketone from the conversion of caprylic acid in the liver) -> more ATP in the infected cells where Bb is "robbing" (fermenting) glucose.
Bb needs glucose...so do we. But in a JAM, WE can use ketones to make ATP.
This is how the medicinal food for AD called Axona works. The active ingredient in it is caprylic acid and it is added to many nutrients similar to those in "Ensure". It is very expensive and takes TIME to work.
I believe it is critical to get the inflammation down (via the Omega 3s) WHILE hitting Bb.
OmegaBrite is very high in EPA, has some DHA and a tad of vitamin E to prevent the oxidation of EPA and DHA.
Personal note...family here for a week. Had a great visit and went to WDW...
Gotta run...washer and dryer are signaling my attention ;-)
P.S. I am in no way affiliated with the OmegaBrite company, but my son takes it (ADHD, Asperger's, etc.) and benefits by it. My sister's C reactive protein is the lowest it has been in years since she began taking OmegaBrite about 3 months ago.
It WORKS...IMO.
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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posted
One concern I have regarding high dose EPA formulations is immune suppression.
720mg of EPA in one study was shown to reduce killer cells.
Now, if this is immune modulation, perhaps it's not as big a deal. But this would need to be tested on sickly people to see how they'd react. If actual immune suppression, which may be the case based off of rodent studies, then I'm not so sure it's a great idea for Lymey people.
Posts: 584 | From NY | Registered: Feb 2009
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Humira, Enbrel, many/most abx. (including Tetracycline), probiotics, specific nutrients...
"Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-B activity and is sufficient to
promote HIV replication
in the cocultures with TEC.
However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient
posted
i'm looking for a good source of fish oil-- they usually upset my tummy--where do you buy omegabrite from?
is it pricey? oh glad it's helping your family!
Posts: 255 | From - | Registered: Jun 2009
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
For me, and I'm not dissing OmegaBrite whatsoever- just personal experience... It did not help with my inflammation, symptoms, etc. I did a 2 month round of it.
I am now on krill oil and alternate it with my former brand of Omegas. I am digging the krill oil. Not sure if it's helping in terms of lab numbers, as I've only been on it for a couple of weeks and haven't had anything recently tested in that regard, but it gives me a slow-burning energy boost and my joint pain seems to have diminished some. I've also recently changed treatment, so that's probably more so the reason, but who knows.
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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My three kids and I are on this now. It's been two weeks and haven't noticed anything positive yet.
Anyone one else get benefit from this?
Any recommends? I've done a little research on other brands.
Carlson's never did anything for us. Nordic Naturals did nothing. Krill oil didn't do anything.
I've heard that Blue Ice a fermented form of Cod liver oil is best. GreenPastures sells it. Any one try this one?
Thanks
-------------------- Bart Henslea 1976 Fibro/CFS/arthritis 2004 Lyme diagnosed 2007 3 1/2 years treatment with oral combos, Cowden, IV roc. BW herbs. Off all abx in 12/10. Feeling good. Posts: 647 | From NY | Registered: Dec 2007
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momlyme
Frequent Contributor (1K+ posts)
Member # 27775
posted
One thing I learned quite recently is that if you take your oils and your vitamins at the same time they make soap in the stomach and nothing is absorbed. So, space these out. Oils can be taken on an empty stomach and vitamins should be taken with a diverse meal.
My son used to take "Odorless" Fish Oil from Nature's Bounty 1000mg. The only reason I put odorless in quotes is because my son says it smells. I kept it in the fridge to keep the smell down but he still says it smells. I don't smell anything bad... he is very smell sensitive.
One thing I didn't like about the Nature's Bounty is it says it has EPA and DHA - but it doesn't say how much of each. Where most labels will say the ammount... Nature's Bounty only says ****?
How do they get away with not labeling properly?
The Nature's Bounty was the first bottle of fish oil I bought in my life... back in August, when I first found Lymenet and ILADS guidelines. I bought it because it said Omega 3 and 6... which was written in the guidelines that you need both.
Of course if you read the guidelines properly, which I DID NOT. You see that the GLA omega-6 oils should come from liquid plant oil. And the fish oil should come from krill oil and NOT fish oil.
Now he takes Arctic Pure Krill Oil - it's only 500mg and the one we take is made by Arctic Pure. We get it from vitacost.
As for plant oils... we get those from foods like flax seeds, sesame oil, olive oil, almond butter, wanuts, walnut oil... and probably more. My son is not much of a meat eater and we had to cut out fish because he is pretty metal toxic... so he gets plenty of nuts and seeds.
I have nothing to do with the product that is being sold on that page. It has a similar name to the one that I take... but like I said, I get mine from vitacost and I pay considerably less for it! (thank goodness!!!)
-------------------- May health be with you!
Toxic mold was suppressing our immune systems, causing extreme pain, brain fog and magnifying symptoms. Four days after moving out, the healing began. Posts: 2007 | From NY/VT Border | Registered: Aug 2010
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