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» LymeNet Flash » Questions and Discussion » Medical Questions » SSRI for lyme related cognitive problems

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Author Topic: SSRI for lyme related cognitive problems
rob48
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Anyone out there that has taken an SSRI to help with cognitive impairment from Lyme? I read somewhere that SSRI's and lyme are not a good mix but I besides taking my anti-botics from my llmd I wanted to try something else to help with my cognitive problems.
Posts: 11 | From Cumberland, Maryland | Registered: Apr 2010  |  IP: Logged | Report this post to a Moderator
sutherngrl
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I hate SSRI's! They make me feel worse. There are other pysch meds that work much better than antidepressants.

What exactly are your cognitive problems?

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rob48
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Short term Memory loss, word retrieval, verbal fluency, loss for words, word recognition. I stated to experience the cognitive problems about a year ago. The fatigue stated about 7 years ago and joint pain, aches, tingling, etc. started about 3 years ago.
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bcb1200
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I'm on 20 mg Prozac. Started it before my Dx as I had bad anxiety. Fell pretty good today.

--------------------
Bite date ?
2/10 symptoms began
5/10 dx'd, after 3 months numerous test and doctors

IgM Igenex +/CDC +
+ 23/25, 30, 31, 34, 41, 83/93

Currently on:

Currently at around 95% +/- most days.

Posts: 3139 | From Massachusetts | Registered: May 2010  |  IP: Logged | Report this post to a Moderator
Jin
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Dear rob48,
I was placed on an SSRI years ago, and have yet to be able to get off of it due to withdrawal. The severity is extreme. These drugs are dangerous, and should never be used! A reporter named Doug Kennedy began investigating them in 2002. What he found was startling. A number of those teenagers who flipped out and shot up their schools had been placed on SSRIs only a few short weeks prior to the incidents.

If you attempt to go off of these medications, they often cause intolerable withdrawal. Many people have taken their own lives as a result of going off of them without weaning. Even being weaned, withdrawal may be unbearable. I wish I could get off of them. In many cases, Kennedy found the drugs were no more effective at alleviating depression than placebo! Another concern is these medications have been found to interfere with absorbing calcium and B-Vitamins.

Your issues would likely be worsened by taking SSRIs. They may actually increase your mental fuzziness. Fatigue tends to be caused as a side-effect. Someone who has Bipolar Disorder would have a worsening in their symptoms according to an article I read recently on everydayhealth.com. The only way these pills would make me feel better is if money magically appeared every single time I took one. Being ill and worried constantly are the primary sources of my distraction.

Sincerely,
Jin

--------------------
Celiac Disease (2007)
Candida Overgrowth (2006)
Thyroid Disease (2004)
Gallbladder Disease (removed- 2003)
Fibromyalgia (2001)
Ovarian Cysts (5 in less than 10 months - 2000)
Anemia (2000)
IBS (1999)
Acid Reflux (1999)

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DeniseNM
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I've been on Prozac for a few years, and have no trouble with it. I like it - I feel much better on it! Don't really think it helps with the cognitive stuff, though.

I also take LDN, and I think that my help some with the cognitive issues.

--------------------
dx: MS in 1998
2007 - Lyme suspected
2009 - Positive Lyme, MS worse. Now: Copaxone shots for MS
gall bladder out 7/09
Ceftin, Zith, Septra
LDN
Acyclovir
Monolaurin, DHEA, Pregnonelon, Curcumin

Posts: 243 | From New Mexico | Registered: Feb 2007  |  IP: Logged | Report this post to a Moderator
rob48
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I had actually been on proazc for about 10 years prior to Lyme dx. I had thought that perhaps the prozac was causing or contributing to my brain fog and cognitive difficulities so I went off cold turkey. Been off now for about 3-4 months.
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kday
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SSRI's are evil drugs.

EVIL.

If I wanted to feel more tortured than I already am, I would take them.

Sorry to those that benefit from this drug class.

Then again I take benzos (tranquilizers). They are very addictive, but since they can actually help ME sometimes, they aren't as evil as others try to make them.

I didn't sleep all night. I had the feeling of doom (yes, to the point where you truly FEEL like you are dying) the whole night. I am having a herx. I resisted benzos all night.

I regret it. It would have been nice to get some sleep. I needed it. Tolerance really should be the last thing I worry about in situations like last night.

I think LDN can help in the presence of excess glutamate. I think this is why I immediately feel better after Rocephin infusions (on good days).

Anybody with severe anxiety with cognitive issues try LDN? I suspect it could work for me considering how much Rocephin reduces anxiety and cognitive issues (better than benzos some days).

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Marnie
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The highest levels of Prozac do look to help some people with lyme.

Serotonin - histamine connections.

If you have a genetic tendency to high levels of histamine naturally (then lyme in addition), SSRIs may indeed help.

Bb looks to NEED tryptophan as it cannot grow without it.

Serotonin is broken down AFTER it does its "help" transferring a signal.

We "reuse" our neurotransmitters. We MAKE them , use them, break them down, remake them, use them...

As I understand it...

Tryptophan -> serotonin -> receptor -> message sent -> serotonin broken down until we make it again to do the same.

This is all happening at incredible speeds.

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Keebler
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-
GOTU KOLA
--------------

Gotu Kola (not a cola) can calm the nervous system while also helping with alertness. It helps give a sense of well-being without feeling ``wired'' or ``hungover''.

Of everything I've used over the years, I cannot say enough good about the wonderful effects I've seen - in many ways - from Gotu Kola.

=======================

www.ncbi.nlm.nih.gov/sites/entrez

PubMed Search:

Gotu Kola - 257 abstracts

Centella asiatica - 245 abstracts

Gotu Kola, seizures - 3 abstracts

Gotu Kola, brain - 29 abstracts

Gotu Kola, cognitive - 8 abstracts

Gotu Kola, depression - 8 abstracts

Gotu Kola, anxiety - 6 abstracts

Gotu Kola, startle - one abstract

(#1: Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity.)

====================

http://www.vrp.com/articles.aspx?page=LIST&ProdID=art799&search_in=articles

GOTU KOLA -- An Under-Appreciated Herb: Multifaceted Benefits on Microcirculation for Cardiovascular and Cognitive Health -- By Linda Fugate, PhD

The best nutrition in the world will not do anyone any good if it doesn't reach our tissues. The gatekeeper to tissues is the microcirculatory system, which includes blood vessels smaller than 0.1 mm in diameter. The health of the microcirculatory system is now recognized as critical to the total health of the individual. (1)

Gotu Kola's Effect on the Circulatory System . . . .

From Wound Healing to Brain Health . . . .

. . . Gotu Kola's primary action is enhancement of the health of the circulatory system. Because circulation is critical to the health of the entire body, Gotu Kola offers benefits in a variety of conditions.

The antioxidant and collagen supportive functions of Gotu Kola are particularly important in enhancing healing of damaged tissues. . . .

- Full article - and citations - at link above.

=========================

From: The One Earth Herbal Sourcebook (Tillotson, et.al.)

http://oneearthherbs.squarespace.com/important-herbs/gotu-kola-leaf-centella-asiatica.html

GOTU KOLA LEAF (Centella asiatica,)

. . . bitter and astringent in taste and cooling in action. It is a brain and memory tonic, and an anti-poison, and very useful for wound and skin healing. . . .

. . . TAM doctors use it as a brain and memory tonic, and have found it especially useful in children.

In Nepal, during the ceremony for the first day of spring, gotu kola leaf is given to schoolchildren to help them in their studies by improving memory and concentration.

It is very safe and extremely effective. TAM doctors also use it to cleanse the system of toxins and reduce inflammation. TCM doctors use gotu kola to clear up boils and toxic fevers. . .

The primary effects of gotu kola include both wound healing and improvement of mental clarity and emotional balance. . . .

. . . * The Indian Central Council for Research on Ayurveda and Siddha, citing more than ten pharmacological and animal studies of gotu kola, also found evidence of the following characteristics:

CNS depressant [calming without causing drowiness], memory enhancer, ** anti-convulsant, ** antispasmodic, behavior and intelligence enhancer, and blood sugar regulator (Pandley et al., eds, 1996).

- Full chapter at link above.

===========================

http://findarticles.com/p/articles/mi_m0FDN/is_1_12/ai_n27234590?tag=content;col1

Centella asiatica

Alternative Medicine Review, March, 2007

-============================

One of the solutions mentioned (by Tillotson) for calming is Seven Forests Acorus Tablets. A search will bring up sources and the ITM link in the article takes you right to a research article about that.

I have taken many of the things suggested and, while no longer a child and not (exactly) ADD, I have a very sensitive system and would be glad to share my experiences with certain things if that helps.

===========================

From: The One Earth Herbal Sourcebook (Tillotson, et.al.)

http://oneearthherbs.squarespace.com/diseases/attention-deficit-disorder.html

Attention Deficit Disorder

================

www.itmonline.org/arts/add.htm

Chinese Herbal Treatment for Attention Deficit Disorder

Attention Deficit Disorder (ADD) is a broad syndrome that may include hyperkinetic syndrome, hyperactivity, and Attention Deficit Hyperactivity Disorder (ADHD).

=====================

Acorus was mentioned in an link above as being calming. Here is more on that:

http://www.ncbi.nlm.nih.gov/sites/entrez

PubMed Search:

Acorus - 153 abstracts

Neuroprotective herbs - 35 abstracts

==================

http://www.itmonline.org/arts/neuro.htm

Neuroprotective Herbs and Active Constituents Approaches to Preventing Degenerative Diseases

by Subhuti Dharmananda, Ph.D.
-

Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
Keebler
Honored Contributor (25K+ posts)
Member # 12673

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-
Tai Chi or Qi Gong (which involves less turning of the head) can be wonderfully helpful to all body systems in many ways.
-

Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
Keebler
Honored Contributor (25K+ posts)
Member # 12673

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-
http://www.tillotsoninstitute.com/important-herbs/turmeric-root-curcuma-longa.html

TURMERIC ROOT (Curcuma longa)

WHAT IT DOES: Turmeric root is bitter in taste and warming in action. It strongly reduces inflammation and mucus in all parts of the body, protects the liver, lungs and intestines .
. . .

SAFETY ISSUES: Due to mucin-reducing effects, do not use the concentrated extract (curcumin) or oil in high doses, especially if you have bile duct obstruction, gall stones, or stomach ulcers. Use turmeric as a spice freely.



- full article at link above. From ``The One Earth Herbal Sourcebook'' (Tilltoson, et.al.)


===================

http://www.ncbi.nlm.nih.gov/sites/entrez

PubMed Search:

Turmeric - 1517 abstracts

Curcumin - 3176 abstracts

Curcumin, pain - 25 abstracts

Curcumin, depression - 19 abstracts

Curcumin, anxiety - 5 abstracts

Curcumin, diabetes - 113 abstracts

Curcumin, inflammation - 291 abstracts

Curcumin, adrenal - 18 abstracts

Curcumin, cardiac - 63 abstract

==================

http://www.ncbi.nlm.nih.gov/pubmed/17479421

Nat Prod Res. 2007 Apr;21(4):328-33.

Anti-babesial compounds from Curcuma xanthorrhiza.

====================

www.ncbi.nlm.nih.gov/pubmed/19540859

Xu Y, Lin D, Li S, Li G, Shyamala SG, Barish PA, Vernon MM, Pan J, Ogle WO.

Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.

Neuropharmacology. 2009 Sep;57(4):463-71.

===================

From Vitamin Research Products:

http://www.vrp.com/ArticlesSearch.aspx?k=Curcumin

Search results for Curcumin - 46 Articles Found

one of those:

http://tinyurl.com/y8bd9k2

Curcumin Prevents Some Stress-Related Changes

Excerpts:

A recently published study investigated the effects of curcumin, a constituent of the botanical turmeric, on changes in cognition and memory caused by stress. . . .

In this new study, researchers investigated the effect of curcumin supplementation on stress-induced learning defects in mice. . . .

The results of the study showed that curcumin reversed memory deficits in a dose dependent manner, meaning increasing dosages of curcumin provided increasingly improved memory in the mice.

In addition, curcumin reversed the stress-induced increase in the levels of serum corticosterone, the primary hormone secreted during the stress response.

The researchers also found that the effectiveness of curcumin was similar to the effects of a tri-cyclic antidepressant.

. . . inhibited changes due to corticosterone-induced toxicity including preserving nerve cell connections, and inhibiting the corticosterone-induced activation of the enzyme calcium/calmodulin kinase II and stimulated glutamate receptor expression, which play a role in neurotransmitter secretion and certain kinds of memory and learning.

The researchers concluded, ``Thus, curcumin may be an effective therapeutic for learning and memory disturbances as was seen within these stress models, and

its neuroprotective effect was mediated in part by normalizing the corticosterone response, resulting in down-regulating of the phosphorylated calcium/calmodulin kinase II and glutamate receptor levels.''
-

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