posted
But only subjective symptoms, because that is the only kind he recognizes. More questionable NIH grants. Are they never going to get this right? And why are they ignoring neurological lyme. They still think this is only an arthritic disease apparently.
This description is completely infuriating.
------------------------------------------------
Project Number: 1R01CK000152-01 Contact Principal Investigator: WORMSER, GARY P Title: SUBJECTIVE SYMPTOMS AFTER TREATMENT OF LYME DISEASE Awardee Organization: NEW YORK MEDICAL COLLEGE
Abstract Text: DESCRIPTION (provided by applicant): Symptoms Lyme disease is the most common tick-borne infection in North America. Although the outcome after treatment is generally excellent, some patients complain of persistent subjective symptoms such as fatigue, musculoskeletal pains, or problems with concentration and memory despite resolution of the objective signs of the disease.
However, these symptoms are also common in the general population and a causal association between Lyme disease and persistent symptoms has not been established.
An unanswered and critically important question is whether, after treatment for Lyme disease, patients are more likely to have chronic (>6 months) subjective symptoms than are individuals who did not have Lyme disease. Note to the worm: lyme doctors can tell them the answer to this without the study.
To answer this fundamental question, we propose to conduct the first prospective, controlled longitudinal cohort study in the United States in which subjects with and without Lyme disease are carefully evaluated in a similar manner for a full year.
This study will also be the first to be able to determine the incidence of post-Lyme disease syndrome (PLDS) and the associated medical complications and economic costs. We will also obtain a blood sample from such patients to be shared with other investigators for future research on possible biomarkers associated with PLDS.
Finally, in a different cohort of patients, we will describe for the first time the outcome of culture-confirmed patients with EARLY Lyme disease more than 10 years after diagnosis and treatment. Note to the worm: early lyme is not the problem, late lyme is the problem. You are studying the wrong group.
PUBLIC HEALTH RELEVANCE: The purpose of our study is to determine whether patients treated for Lyme disease are more likely to have persistent symptoms than individuals who did not have Lyme disease.
To answer this fundamental and previously unanswered question, we propose to conduct the first prospective study in the United States in which subjects with and without Lyme disease are carefully evaluated in a similar manner for a full year.
In a different group of patients, we will describe for the first time the outcome of patients with early Lyme disease more than 10 years after diagnosis and treatment.
[ 09-11-2010, 10:48 AM: Message edited by: lou ]
Posts: 8430 | From Not available | Registered: Oct 2000
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posted
And here is another one funded by NIH, which says IgG declines in successfully treated lyme disease, so they are going to tell all of us seronegative cases that we are cured! Why bother doing the study if they already have the answer they want? Oh, I know. To get the money. The money being $278K. And that money is going to a commercial company which will then make more selling this bogus test. It will be a real money maker because every insurance company is going to require it.
Project Number: 1R43AI085725-01 Contact Principal Investigator: LEDIZET, MICHEL Title: A SEROLOGIC ASSAY TO MEASURE SUCCESSFUL LYME BORRELIOSIS ANTIBIOTIC THERAPY Awardee Organization: L2 DIAGNOSTICS, LLC
Abstract Text: DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 20,000 cases reported to the CDC annually.
There is controversy over the length of antibiotic therapy that is necessary to achieve a clinical cure for Lyme disease. Serologic tests (ELISA and immunoblot) that detect antibodies against B. burgdorferi are currently the most sensitive and widely available laboratory tests for Lyme disease, but they do not assess response to therapy and can not distinguish previous exposure to B. burgdorferi from active infection.
The determination of when a laboratory cure is achieved after antibiotic treatment remains a large, unmet medical need for distinguishing acute infection or re-infection from previous exposure and for preventing unnecessary treatment with long-term courses of antibiotics.
To address this need, we have assessed antibiotic therapy in the mouse model of Lyme borreliosis. We found that IgG responses decline rapidly to a subset of Borrelia antigens after successful antibiotic therapy. This Phase I proposal seeks to improve upon the currently available serologic tests for Lyme disease through a proteomic approach that will a) identify the B. burgdorferi antigens to which murine antibody responses decline after successful antibiotic treatment and b) evaluate their diagnostic potential in distinguishing active infections from those cured with antibiotics.
Declines in titer or loss of reactivity to the antigens will be correlated with antibiotic sterilization that will be confirmed by multiple measures. The candidate diagnostic antigens will be produced as recombinant proteins and tested for reactivity with sera from mice treated with antibiotics at different stages of infection and patient sera representative of various stages of B. burgdorferi infection.
The specificity and sensitivity of these diagnostic tests in patients will be determined in Phase II, and quantitative ELISA assays that predict successful elimination of infection by antibiotics will be developed for use in commercial clinical laboratories.
PUBLIC HEALTH RELEVANCE: Lyme disease is an infection with the tick-transmitted spirochete Borrelia burgdorferi.
Some people have lingering symptoms even after antibiotic therapy, and there is no test to determine the effectiveness of antibiotics at eliminating the infection. Our intent is to significantly improve the evaluation of patients treated for Lyme borreliosis through the introduction of new serologic tests that predict when infection has been cured and distinguish prior exposure from active infection.
Public Health Relevance Statement: PROJECT NARRATIVE Lyme disease is an infection with the tick-transmitted spirochete Borrelia burgdorferi. Some people have lingering symptoms even after antibiotic therapy, and there is no test to determine the effectiveness of antibiotics at eliminating the infection.
Our intent is to significantly improve the evaluation of patients treated for Lyme borreliosis through the introduction of new serologic tests that predict when infection has been cured and distinguish prior exposure from active infection.
Posts: 8430 | From Not available | Registered: Oct 2000
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Rivendell
Frequent Contributor (1K+ posts)
Member # 19922
posted
The biggest mistake during the 1980's was allowing researchers/scientists to patent their discoveries. Now they will do everything in their power to destroy any evidence that proves their original hypothesis wrong.
It seems that greed is behind just about every major problem that exists right now.
What do we do? How do we force the government to look at the alternative, and very powerful research on this issue. It is all about making money now. Not spending money to help people.
Posts: 1358 | From Midwest | Registered: Apr 2009
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janet thomas
Frequent Contributor (1K+ posts)
Member # 7122
posted
More of our tax dollars used wisely.
-------------------- I am not a doctor and this is not medical advice but only my personal experience and opinion. Posts: 2001 | From NJ | Registered: Mar 2005
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2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
It's all about money.
The next person to shake his hand needs to bring their little friend.
Let that "little sucker" get right where it needs to go and wormser will be to sick to do any research and might be more willing to listen and learn.
We'll call it "Handshake Warfare", the TICKing time bomb.
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
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posted
"some patients complain of persistent subjective symptoms such as fatigue, musculoskeletal pains, or problems with concentration and memory despite resolution of the objective signs of the disease."
Guess what? Problems with concentration and memory are not SUBJECTIVE. They can be proven via neuropsych evaluation or a visit to a good neurologist. That's mistake #1 which is in paragraph #1.
I began to read more and saw "economic costs" so I had to stop. "Economic costs?" Don't even get me started.
In the second article, I just scrolled down to the last statement.
"Our intent is to significantly improve the evaluation of patients treated for Lyme borreliosis through the introduction of new serologic tests that predict when infection has been cured and distinguish prior exposure from active infection."
Let me guess. The new serologic tests will be patented.
I am doing some deep breathing.
-------------------- You gain strength, courage, and confidence by every experience in which you really stop to look fear in the face. You are able to say to yourself, 'I lived through this horror. I can take the next thing that comes along.'
---Eleanor Roosevelt Posts: 748 | From somewhere | Registered: May 2010
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
I think we should all go volunteer for the study.
Would that freak them out or what? They would actually have to LISTEN to us... for a few minutes at least.
That MIGHT make the tax-payers money they are getting to do this study worth it.
But then with the Worm's criteria we would all be put in the well-person category ... allowing him to prove those with post-Lyme syndrome only have the "aches and pains of daily living".
But he already KNOWS that.
Who here doesn't already know the outcome of that study?
Maybe we could talk Congress into giving the money to a fund for Dr. Jones? Or to help pay for medicines for those who can't afford it?
Or maybe they can just set the money on fire now and let it burn, for all the good it will do.
Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
I also noted a study being done to find a test that will determine when we've been cured by antibiotic therapy. It is being done by a private company... with a highly questionable back ground.
Oh.. and there are other IDSA authors that will be cashing in on our "disease". Ain't that just dandy?
If you can stomach it, take a look at some of the tick borne disease related grants.
But don't be eating while reading it. Not without some Pepto Bismol right by your bedside.
posted
I posted this on Mr Blumenthols facebook page ! I hope many others jump on that post too and ask him the same question since hes running for congress! time for him to poop or get off the pot.
question Mr Blumenthal are you ever going to finnish what you started with the idsa and the cdc or are the red blooded lymies of this country going to have to keep dying because of their greed. november is fast approaching and we will not forget who helped us and who blew smoke up our keisters we will speak through our votes !
we all were excited when you took them on in court but nothing has changed since then people with lyme are still dying because of that greed !
Posts: 294 | From sw chicago suburbs | Registered: Apr 2007
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posted
If the worm is so confident in his beliefs ,
then why doesn't he allow a tick to bite him,
then go four years without any treatment,
none, not even in the first 8 weeks,
that is what happens to most people,
THAT! would be a great study,
he can see if he gets a bullseye rash,
he can see if he tests negative of the ELISA
he can see if he is just a "little depressed" and prescribe himself some antidepressents,
he can see if he starts to get excrutiating pain, numbness, twitching, fatigque and start to journal his experience,
oh, but at this point, maybe he will keep forgetting to do it, or maybe he will be too tired!, or maybe he will be too dyslexic, or too weak, or too confused!,
I am so mad!
Posts: 606 | From somewhere out there | Registered: Sep 2009
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then he can add a HUGE amount of steriods to his system,
HUGE AMOUNT!
DID I SAY I WAS MAD???????!!!!!!!!!!!!!!!!!!! eeeerrrrrrgghgggggggg!!!!!!!!!!!!!!!
Posts: 606 | From somewhere out there | Registered: Sep 2009
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2roads
Frequent Contributor (1K+ posts)
Member # 4409
posted
"Handshake Warfare"....anyone willing to go?
Posts: 2214 | From West Chester, PA | Registered: Aug 2003
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Just name the day and time and I will be there!
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
They say they are getting no economic benefit from the easily cured, no persistent infection stance. What do you call a $300K+ reward?
And sorry pj, Mr. Blumenthal has done everything he can to help and can't do more. A state AG cannot be the arbiter of what is good medicine. Only the federal govt and medical establishment can do that, and they are not doing it. In fact, the medical bureaucracies have done everything they can to hurt us.
When you see how they have stiffed the CFS people, autistic children, gulf war vets, etc, then you would have to conclude that we would be better off without them. Bureaucracies typically empire build and find ways to reward individual bureaucrats. Their initial purpose for existing is given lip service and nothing else.
[ 09-12-2010, 02:37 PM: Message edited by: lou ]
Posts: 8430 | From Not available | Registered: Oct 2000
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posted
Just a reminder here on this notion of "culture-negative." The testing method mentioned in the study was invented over 100 years ago -- less than 10% of microbes can be cultured with this archaic technology. Hence, the frequent mentions of sero-negativity...
Given the number of people afflicted with chronic bacterial diseases, does it make sense to use the most advanced testing -- molecular diagnostics? Of course it does.
The absurdities lie between the lines of these doomed studies. In the meantime, our tax dollars continue to be thrown away on these "studies."
-------------------- My biofilm film: www.whyamistillsick.com 2004 Mycoplasma Pneumonia 2006 Positive after 2 years of hell 2006-08 Marshall Protocol. Killed many bug species 2009 - Beating candida, doing better Lahey Clinic in Mass: what a racquet! Posts: 830 | From Mass. | Registered: Aug 2006
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posted
No matter the study, if it's run by IDSA ducks, the result will be the same.
Right on, missing!
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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WildCondor
Unregistered
posted
I needed the Pepto Bismal Tincup, maximus vomitus!
Looks like clown face needs more $ for a new house more botox injections, and more fancy trips around the world. They are all a joke, the patients (atleast most of them) know better these days. Eventually they will all sit down (probably when they become infected, or a family member does) Secrets will come out eventually. They will continue living their lie in the meantime.
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Firstly how are they going to get anyone who has Lyme to give them their blood?
And secondly why can't we make it where each donor has to send a sample to Igenex at draw
with a chain of command/rule of law in place
whereby Igenex gets paid for every sample they test===same as the worm???
If the NIH refuses we can always take it to the Supreme Court for flagrant use of federal funds, given to a group who cannot even read the current literature!!!!
Move over Bernie Madoff you might have company...
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
You watch===they are going to try to find some
little something to get their own patent so they
can claim their piece of the pie. While all these
years they have lied to the public causing
unimaginable pain and suffering.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
Had 2 patients who are suffering severely with ALS who went seeking treatment by a quack and challenged the thief's with their lies....They were lieing.
But they failed to give any explanation of any good research that has shown great outcomes....
They are doing all they can in this dept. also to keep people sick....
Next it will be IVIG and then the rest of our supp.s.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
I saw 60 min tonight about stem cell quackery. I heard the interviewer say that no one has ever been cured of ALS. Does 60 minutes not know of the multitude of mis diagnosis for lyme? Have they not read cure unknown? What about poor Bart from San Jose Ca who was Dx with ALS and after being treated for lengthy IV ABX Rx ended up being able to walk out of the hospital, after almost being near death. I know nothing about stem cell curing any ALS patients but I have read about a number of these patients that have been cured when treated for Lyme, which should have been the Dx in the first place. Does someone here keep track of the number of patient misdiagnoses...would be good to send to 60 min
Posts: 21 | From california | Registered: Jul 2008
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Well they wouldn't post mine...I spoke nothing but the truth.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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