Article posted - "Kaiser Halts Perscribing"
Two different things totally!

So do you have information that supports Bextra production has stopped?

Below is a Labratory analysis of the eccects of a molecule called a Xanthone.

It comes from a fruit caled the Mangosteen (NOT a Mango)

This natural substance is available in liquid form, tastes great, and has helped thousands of people with pain from inflamation.

I along with several others have used it and it works.
www.mangosteenmd.com

It available ONLY through licensed distributors, and not in stores.
www.iowamangosteen.com

I can send you to one if you would like to take a substitute.

TRout

PS I am adding another abstract showing its anti-bacterial affects.
3: Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y.
Inhibition of cyclooxygenase and prostaglandin E2 synthesis
by gamma-mangostin,a xanthone derivative in mangosteen, in
C6 rat glioma cells.
Biochem Pharmacol. 2002 Jan 1;63(1):73-9.
PMID: 11754876 [PubMed - indexed for MEDLINE]
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y.
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan.
The fruit hull of mangosteen, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia. In the present study, we examined the effect of gamma-mangostin, a tetraoxygenated diprenylated xanthone contained in mangosteen, on arachidonic acid (AA) cascade in C6 rat glioma cells. gamma-Mangostin had a potent inhibitory activity of prostaglandin E2 ( PGE2) release induced by A23187, a Ca2+ ionophore. The inhibition was concentration-dependent, with the IC50 value of about 5 microM. gamma-Mangostin had no inhibitory effect on A23187-induced phosphorylation of p42/p44 extracellular signal regulated kinase/mitogen-activated protein kinase or on the liberation of [14C]-AA from the cells labeled with [14C]-AA. However, gamma-mangostin concentration-dependently inhibited the conversion of AA to PGE2 in microsomal preparations, showing its possible inhibition of cyclooxygenase (COX). In enzyme assay in vitro, gamma-mangostin inhibited the activities of both constitutive COX (COX-1) and inducible COX (COX-2) in a concentration-dependent manner, with the IC50 values of about 0.8 and 2 microM, respectively. Lineweaver-Burk plot analysis indicated that gamma-mangostin competitively inhibited the activities of both COX-1 and -2. This study is a first demonstration that gamma-mangostin, a xanthone derivative, directly inhibits COX activity.
PMID: 11754876 [PubMed - indexed for MEDLINE]

Antibacterial Abstract

16: Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R, Miyauchi K.
Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus.
J Pharm Pharmacol. 1996 Aug;48(8):861-5.
PMID: 8887739 [PubMed - indexed for MEDLINE]
Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus.
Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R, Miyauchi K.
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Extracts of Garcinia mangostana (Guttiferae) showing inhibitory effects against the growth of S. aureus NIHJ 209p were fractionated according to guidance obtained from bioassay and some of the components with activity against methicillin-resistant Staphylococcus aureus (MRSA) were characterized. One active isolate, alpha-mangostin, a xanthone derivative, had a minimum inhibitory concentration (MIC) of 1.57-12.5 micrograms mL-1. Other related xanthones were also examined to determine their anti-MRSA activity. Rubraxanthone, which was isolated from Garcinia dioica and has a structure similar to that of alpha-mangostin, had the highest activity against staphylococcal strains (MIC = 0.31-1.25 micrograms mL-1), an activity which was greater than that of the antibiotic vancomycin (3.13-6.25 micrograms mL-1). The inhibitory effect against strains of MRSA of two of the compounds when used in conjunction with other antibiotics was also studied. The anti-MRSA activity of alpha-mangostin was clearly increased by the presence of vancomycin; this behaviour was not observed for rubraxanthone. The strong in-vitro antibacterial activity of xanthone derivatives against both methicillin-resistant and methicillin-sensitive Staphylococcus aureus suggests the compounds might find wide pharmaceutical use.
PMID: 8887739 [PubMed - indexed for MEDLINE]

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Now is the time in your life to find the "tiger" within.
Let the claws be bared,
and Lyme BEWARE!!!
Iowa Lyme Disease Assoc. www.ildf.info

[This message has been edited by troutscout (edited 02 February 2005).]