Topic: Dr. Ed Masters, discoverer of STARI has passed away
Melanie Reber
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posted
Dear friends,
I am so saddened to bring this news. Dr. Masters was a beacon in the Lyme world and will be sorely missed.
...
(6-21-09)
"Dr. Masters fought long and hard to prove the existence of Lyme disease in the south. He died this morning after a long series of health problems related to complications from diabetes.
Dr. Masters' funeral is to be held Wednesday, June 25, 2009, at 10:30 a.m. Services will be at First Christian Church, 1006 N. Main Street, Sikeston, MO 63801
Cards may be sent to Ferguson Medical Group, 1012 N. Main, Sikeston, MO 63801.
The family is asking that in lieu of flowers donations be made to the Lyme Disease Institute, First State Bank and Trust, c/o Linda Scott, P.O. Box 1830, Sikeston, MO, 63801.
The Lyme Disease Institute was formed around 18 years ago to further education and research into Lyme disease in the south. LDI helped fund many of Dr. Masters' research projects. "
...
Dr. Masters was the discoverer of Borrelia lonestari - Southern Tick Associated Rash Illness (STARI or Master's disease).
The following is a quote from Coping with Lyme Disease, by Denise Lang:
(Begin quote)
``Dr. Edwin Masters, of Cape Girardeau, describes himself as a ``simple country doc,'' but his quick grin and folksy homilies can't hide his acuity and concern when discussing the nearly one thousand cases of the disease he has diagnosed but cannot get his state to recognize.
''I'm a tree farmer by avocation, so when the state medical society was holding a conference, they asked me to prepare a talk on Lyme disease. Hell, I didn't know anything about Lyme, and I didn't believe it existed in these parts, but I operate on Masters's Maxim - that is, anything that's worth doing is worth overdoing. I collected hundreds of articles, prepared slides, studies, and presented my findings at the meeting.''
That was the beginning of a five-year crusade, but the major obstacle was the fact that the Ixodes dammini tick, the primary Lyme vector, was not common in Missouri. (End quote)
posted
Thank you for bringing this to our awareness.
Our thoughts and prayers go out to his family.
He was an amazing man who will be missed by many.
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
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Melanie Reber
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That was wonderful reading Terry. I have GOT to get that book! I was really confused though when it mentions that the causative agent of STARI was still not known.
From my research, it IS known, so I'm not too sure why it is stated as such in the book?
....
STARI--a new tick borne spirochetosis Zajkowska J, Moniuszko AM, Czupryna P, Pancewicz SA, Grygorczuk S, Kondrusik M Przegl Epidemiol 2009; 63(1):19-22.
Southern Tick Associated Rash Illness (STARI), also known as Masters disease is caused by Borrelia lonestari spirochetes and it is transmitted by Amblyomma americanum tick. Early symptoms of STARI are similar to early Lyme borreliosis (skin rash resembling Erythema migrans). In diagnostic of STARI traditional methods are not effective. The decision of antibiotic treatment (similar to Lyme borreliosis) still remain based on clinical picture.
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Melanie Reber
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Dr. Ed Masters Monday, June 22, 2009
SIKESTON, Mo. -- Dr. Edwin Jordan Masters, 63, of Sikeston died Sunday, June 21, 2009, at Southeast Missouri Hospital in Cape Girardeau.
He was born July 30, 1945, in Poplar Bluff, Mo., to the late Dr. Edwin Caleb and Bess Jordan Masters. He graduated from Advance, Mo., High School in 1963 and was valedictorian of his class, received his bachelor of arts degree from Dartmouth College in Hanover, N.H. in 1967 and his MD degree from the University of Tennessee in Memphis in 1971. He practiced medicine at the Advance Medical Clinic from 1971 to 1974, Ferguson Medical Group in Sikeston from 1974 to 1987, Family Physicians Group in Cape Girardeau from 1987 to 1995, Regional Primary Care Inc. in Cape Girardeau from 1995 to 2001 and Premier Family Physicians Inc. in Cape Girardeau from 2001 to 2006. He was a member of the Missouri State Medical Association, American Academy of Family Physicians, the American Medical Association and was one of the leading Lyme disease physicians in the world.
He was a member of the First Christian Church in Sikeston and a former member of the Sikeston Jaycees.
He married Jackie Ebaugh in Cape Girardeau on June 21, 1970, and she survives of the home in Sikeston. He is also survived by three sons and daughters-in-law, Ryan and Julie Masters of Quincy, Ill., Jordan and Abbey Masters of Cape Girardeau and Drs. Reid and Jenna Masters of San Diego.
He is also survived by his daughter and son-in-law, Erin and Allen Cryer of Carrollton, Texas; and a sister, Charlotte "Rusty" Newton of the Happy Farm in Advance; and four grandchildren, Ayanna Askew, Anna Cryer, Ezra Cryer and Lydia Masters.
Visitation will be from 5 to 8 p.m. Tuesday at Nunnelee Funeral Chapel in Sikeston.
Services will be at 10:30 a.m. Wednesday at the First Christian Church in Sikeston, with the Rev. Mary McCord, pastor, officiating. Burial will be in Memorial Park Cemetery in Sikeston.
The family requests that memorial contributions may be made to Lyme Disease Institute, c/o Linda Scott, First State Bank & Trust, P.O. Box 1830, Sikeston, MO 63801.
treepatrol
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posted
geez
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
Pinelady
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posted
Yes he was a good Shepherd.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
Very sorry about this. He was an honest and courageous doctor.
I think when they say the cause of lonestari is not known, they mean that no lab has been able to identify it. A lot of labs have tried, apparently. But I personally no longer believe much in lab testing. They only find what they are looking for. When they get good at finding new things, then we can have more confidence in them. But it is clearly spirochetal because it closely resembles lyme disease.
And you know that saying about only the good dying young? Am beginning to believe it is true. The bad ones seem to live forever and never have any health problems. Can only think of two exceptions to that rule in the lyme world, where two bad guys died. I consider Master's death at the age of 63 to be young.
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TerryK
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Good question Mel. Looks like nothing has been proven as far as the causative agent unless something definitive happened between 2008-2009.
From the looks of it, this tick carries multiple strains of borrelia some of which they have not been able to identify/culture.
Despite vigorous efforts, the causative agent of STARI has never been cultured and is not currently known. However, some evidence exists that a recently discovered spirochete, Borrelia lonestari, may be responsible: B. lonestari has been detected by polymerase chain reaction (PCR) in Lone Star ticks removed from humans, as well as in Lone Star ticks collected during general epidemiological studies.
More convincingly, B. lonestari DNA was detected by PCR in the biopsied skin lesion of a patient with a history of recent Lone Star tick bite, while B. burgdorferi DNA was absent in the same sample.
However, other studies have been unable to confirm this finding; in one Missouri investigation, biopsies from the lesions of 31 patients with Lone Star tick bites were negative by both culture and PCR for B. lonestari. Thus, the etiology of STARI remains elusive. It is possible that multiple borrelial species may be responsible.
From Masters in 2008
1: Infect Dis Clin North Am. 2008 Jun;22(2):361-76, viii.
STARI, or Masters disease: Lone Star tick-vectored Lyme-like illness.
Masters EJ, Grigery CN, Masters RW. Ferguson Medical Group, Sikeston, MO 63801, USA. [email protected]
Lyme-like illness (also known as southern tick-associated rash illness [STARI] or Masters disease) is vectored by the Lone Star tick (Amblyomma americanum).
Lyme-like illness lesions, which are similar to the erythema migrans rash of Lyme disease, tend to have lymphocytic dermal infiltrates.
With the exception of Borrelia lonestari, the possible causative agent or agents of Lyme-like illness have not been cultured. More research is needed to fully understand this newly recognized zoonosis.
Clinicians are encouraged to increase their knowledge and awareness of this Lyme disease mimic.
PMID: 18452807 [PubMed - indexed for MEDLINE]
From the Military in 2009
1: Mil Med. 2009 Apr;174(4):419-25.
Prospective health assessment of Fort Campbell, Kentucky patrons bitten by ticks.
Murphree R, Hackwell N, Mead PS, Bachand A, Stromdahl EY.
Centers for Disease Control and Prevention, Division of Vector Borne Infectious Disease, 3150 Rampart Road, Fort Collins, CO 80521, USA.
Amblyomma americanum is an aggressive human-biting tick that transmits several known human pathogens and is associated with a Lyme disease-like illness of unknown etiology.
To determine the frequency, distinguishing clinical characteristics, and etiology of A. americanum-associated illness and identify associated risk factors, a prospective study of adult tick-bite victims was conducted at Fort Campbell from 2005-2007.
Forty-two participants submitted ticks, none of which contained Borrelia lonestari or B. burgdorferi DNA.
Thirty-three participants completed a follow-up health survey; 14 reported at least one symptom; two had erythema migrans-like rash; eight sought medical evaluation for their symptoms.
Findings suggest that a variety of symptoms are temporally associated with tick bite but data provide no clear evidence that reported symptoms were caused by an infectious process. Removing a tick by hand or being bitten on a limb may be a risk factor for illness.
PMID: 19485114 [PubMed - in process]
Don't want to divert this post but here are a few other things that I found. We could always move this discussion to it's own post if you want??
From 2001 http://tinyurl.com/krsotq Lone Star Tick-Infecting Borreliae Are Most Closely Related to the Agent of Bovine Borreliosis
Terry
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Melanie Reber
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Actually, I think it is fitting to leave the discussion here. It was, after all, his lifes work.
I have to shut down for awhile to do some work of my own, but am very interested in following up on what you have posted... it will just have to be later on tonight.
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Sorry, but I thought that the bacteria that causes what is now called Masters disease was first noted by Dr. Masters. Later when it was confirmed, the bacteria and disease was named after him. I know that my LLMD said there was some who thought STARI AND Masters were caused by the same bacteria, but then some did not think so.
My technical diagnosis is late stage neurological Masters disease. My LLMD practice with Dr. Masters for 5 or so years.
I actually prefer the word lyme because sometimes one syllable words are better for me. But my Dr. says if you cant remember Masters then say borreliosis. Again too many syllables.
Either way, Dr. Masters will be missed.
-------------------- Amy
Diagnosed April 29, 2007. Posts: 136 | From Joplin, MO | Registered: Apr 2007
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I received this info from a friend in MO yesterday. Dr. Masters delivered her daughter 30 years ago.
"I just got in from church and while I was there, I found out that Dr Ed Masters died this morning. He had been in bad health for about 10 years. Not only did Dr Masters die on Father's Day, but it was also their anniversary."
~ ~ Hope is a powerful medicine. ~ ~ Posts: 2775 | From MN | Registered: Apr 2001
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bettyg
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so sorry to read this; i know he was still treating folks last year.
i sent to my own lyme list group, fyi only....
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Melanie Reber
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Sikeston mourns passing of well known doctor Tuesday, June 23, 2009 By Scott Welton ~ Standard Democrat
SIKESTON, Mo. -- Family, friends, former patients -- an entire community -- are mourning the loss while celebrating the life of Dr. Ed Masters today.
Masters, 63, died Sunday at Southeast Missouri Hospital in Cape Girardeau.
"It's a loss to the world," said Paul Walters of Alton, Ill., a former patient of Masters making the three-hour drive for today's visitation. "He was an amazing person."
Rusty Newton of Advance, Masters' sister, described Masters as "a renowned and beloved family physician."
"He loved being a doctor," she said. "Solving complicated medical cases was the challenge he relished most."
One of the biggest challenges Masters faced was the one he is best remembered for.
"He spent the better part of his medical career researching, documenting and treating tick-borne diseases and was internationally known for his work with Lyme disease," Newton said.
Due to his extensive research on Lyme-like diseases and a critical discovery, STARI (Southern tick-associated rash illness) is also known today as Masters disease.
"It should be called Masters disease," said Walters, who is among the many treated by Masters for Lyme-like diseases. "Ed Masters is the one who isolated it."
Doctors from all over the country would refer their patients to Masters advising he was "the one man who could help them," Newton said. "People would call to try to get an appointment to see him and couldn't get in."
Some managed to track Newton down at her former home in Kansas City and plead with her to ask her brother to schedule an appointment for them. "And he did on many, many occasions," she said.
Newton recalled how when some patients were too weak to make the drive down here, Masters would drive to meet them at the airport.
"The first time I came to see the man I was just amazed -- I saw license plates from all over the United States in the parking lot," Walters said.
"I had been off work for years trying to find a solution to my illness," he recalled.
And when Walters' health insurance wasn't accepted, "he refused to take my money," Walters said. "He was probably the most decent person I met in my entire life."
Newton noted that Masters also made lasting impressions at another level as a mentor for many promising young students who aspired to be physicians.
Among these is Chelsea Grigery who is now in her fifth year of a six-year bachelor's degree/medical school program at University of Kansas City.
"I credit my acceptance into this program to Dr. Masters," Grigery said. "It is because of him that I am where I am today. I credit my interest in medicine and research to Masters because he opened up so many avenues for me and provided me with so much experience and support."
Grigery worked with Masters on Lyme disease research projects as both a junior and a senior at Sikeston High School in 2004 and 2005.
In the second project, "Dr. Ed was extremely influential in helping that to be a successful experiment," she said. "He used his contacts in the Lyme disease circle of researchers to connect me with the people to help me with this project."
Masters then helped Grigery get the work published in Missouri Medicine.
"I was the youngest author to ever be published in that journal - that is totally thanks to him, Grigery said. "He was by far the most influential person in my young adult life -- a phenomenal physician, educator, researcher. I view him as a father figure -- I was that close to him. Both he and his wife, Miss Jackie, invited me into their home for hours on end to work on these programs and never made me feel unwelcome. Miss Jackie is just a phenomenal woman, an excellent wife and mother and friend. They treated me as one of their own children. He used to joke that I was his fifth child."
"Dr. Masters was most proud of his family. He delighted in their achievements and successes and was lovingly called "Papa Doc" by his grandchildren," Newton said. "He believed that his illness had a very positive gift and that was having more time with his family."
"He always tried to make sunshine out of the rain," Walters agreed.
"Dr. Masters will be remembered not only for his list of achievements but also for his brilliant intellect, wisdom, integrity, optimistic spirit, perseverance in the face of great obstacles, humanity, love of his family and his unique, contagious laugh," Newton said. "He was my hero."
posted
where is the lyme disease instititue? did he found it?
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Melanie Reber
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Hey Miss BG,
That is a really good question. I'm assuming it is in MO? But I'm sorry... I don't have it in me right now to do the research. Perhaps someone who knew him more intimately could help with the answer?
I am also wondering if anyone knows IF he had TBDs himself? M
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bettyg
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mel, happy to hear you didn't know either ... thought it was just me, but now i have company lol
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he will be missed, he truly was a lyme warrior who took on the idsa/cdc and proved to them they are wrong about this disease.
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quote:Originally posted by Melanie Reber: I am also wondering if anyone knows IF he had TBDs himself? M
Melanie,
My friend in MO that goes to the same church as the Masters told me:
"He was a diabetic but he also had an undiagnosed condition that mimics Lyme Disease (I imagine that was how his interest started) that destroyed the lining of the muscles, I think that is what they said. They had tried for years and ran many tests but never had a positive diagnosis of what disease he had. So they aren't sure of a cause but expect that it was a combination of things."
I thought he had Lyme disease.
-------------------- Peggy
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Melanie Reber
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Thank you Miss Peggy.
It is true that many times our LLMDs have dealt with TBDs themselves or have loved ones who have and this usually is why their capacity to care for us is so great.
Being a 'tree farmer' in MO, he certainly had opportunity to become exposed. I have also asked others who might be able to answer this definitively.
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bettyg
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i also posted in medical pam weintraub's psychology today article, A TRIBUTE TO DR. MASTERS, PART 1 ...
go to site and i broke it all up there for us neuros; i'm 1st comment, and pam asked me to break it up there so her numbers stay up on top vs. posting broken up version here.
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Melanie Reber
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Will you provide that link for us Miss BG?
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Melanie Reber
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Dr. Edwin Masters Tuesday, June 23, 2009
Dr. Edwin Jordan Masters, 63, a renowned and beloved family physician, died Sunday, June 21, 2009, the day of his 39th wedding anniversary and Father's Day.
Dr. Masters' life is celebrated for the incredible list of achievements accomplished during his lifetime. He loved being a doctor. Solving complicated medical cases was the challenge he relished most.
He spent the better part of his medical career researching, documenting and treating tick-borne diseases and was internationally known for his work with Lyme disease. His success led to the Centers for Disease Control naming a tick disease after him, called "Masters disease."
Dr. Masters was constantly thinking about how to improve medical care, which led to the granting of seven U.S. medical patents. His insatiable intellectual curiosity resulted in 53 major peer-reviewed articles accepted for publication in major medical publications. His last two articles will appear in the July issue of "Missouri Medical." Dr. Masters mentored many aspiring physicians and one of his joys was judging the International Science Fair for high school students.
Dr. Masters was extremely active in many professional organizations. He was president of Cape Girardeau County Area Medical Society, speaker of the House of Delegates of the Missouri State Medical Association, American Academy of Family Physicians, American Medical Association and chairman of EICS: Emerging Infections in the Central States Research Group.
He was the featured speaker at many international and national medical conferences and received numerous awards for his research in Lyme and vectorborne diseases.
Dr. Masters started practicing medicine in 1972 in partnership with his father, Dr. E.C. Masters, in Advance, Mo. He then moved to Sikeston, Mo., where he joined Ferguson Medical Group for 13 years, and then had an opportunity to join Regional Primary Care and later Premier Family Physicians in Cape Girardeau.
Dr. Masters graduated valedictorian from Advance High School in 1963, received an A.B. degree from Dartmouth College, an M.D. degree from the University of Tennessee Medical School, and completed his internship at Baylor University Medical Center in Dallas. He was a diplomate, National Board of Medical Examiners, a fellow in the American Academy of Family Physicians, on the Board of Certified Family Practice and a diplomate in geriatrics.
Dr. Masters was also known as the "Tree Doc." He started planting walnut trees in his youth and continued throughout his lifetime. He worked aggressively on cultivating new species of walnuts and was president of the National Black Walnut Tree Association and Missouri Tree Farmer of the Year.
His love of and knowledge of nature was inspiring to all. He developed and patented a mosquito and tick trap approved by the FDA that is totally "green" and the only one in the U.S. not dependent on the use of propane.
The "Skeeter Plus" is locally manufactured and distributed by DeWitt Industries.
Politics was one of Dr. Masters' interests. He was a lifelong Republican and early in his career was very instrumental in getting a Republican on the ballot in Scott County.
Dr. Masters was most proud of his family. He delighted in their achievements and successes and was lovingly called "Papa Doc" by his grandchildren. He believed that his illness had a very positive gift and that was having more time with his family. His consistent optimistic spirit and love of sharing his passion for memory games was legendary. He often said the greatest asset he had in life was growing up in a small town and being raised, inspired and taught by two incredible parents.
His survivors include his wife, Jackie Ebaugh Masters, of Sikeston; three sons and daughters-in-law, Ryan and Julie Masters of Quincy, Ill., Drs. Reid and Jenna Masters of San Diego, Jordan and Abby Masters of Cape Girardeau; a daughter and son-in-law, Erin and Alan Cryer of Dallas; four grandchildren, Ayanna Askew, Lydia Masters, Anna Cryer and Ezra Cryer; and a sister and brother-in-law, Charlotte "Rusty" and David Newton of the "Happy Farm" in Advance, Mo.
Dr. Masters will be remembered not only for his list of achievements but also for his brilliant intellect, wisdom, integrity, optimistic spirit, perseverance in the face of great obstacles, humanity, love of his family, and his unique, contagious laugh.
Published in the Southeast Missourian, June 2009
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The world has lost some magic without him as he will be missed as he is loved.
Until we meet again Dr. Masters, i will think of you often and sing your praises as always...with the sweetest of tunes.
He was my treating LLMD for the past 3 1/2 years. (Where did you think i got my boxing *lyme* gloves from? lol) It will be hard to look at the script bottles for the next 8 months without breaking down. But, i know *for a fact* he would not want us sad...not even for one moment...
Melanie Reber
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posted
That is a most beautiful tribute page. Thank you for including the link to read and leave comments for Dr. Masters.
The quote you have above has been one I've used countless times. So profound. He truly was a great healer in so may ways.
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Melanie Reber
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Terry,
If you look at the abstract that I posted earlier, you will see it is from 2009 and clearly states the causative agent of STARI is B. lonestari.
So, unless this was disproven somehow... it seems pretty clear to me that it has been identified.
.....
STARI--a new tick borne spirochetosis Zajkowska J, Moniuszko AM, Czupryna P, Pancewicz SA, Grygorczuk S, Kondrusik M Przegl Epidemiol 2009; 63(1):19-22.
Southern Tick Associated Rash Illness (STARI), also known as Masters disease is caused by Borrelia lonestari spirochetes and it is transmitted by Amblyomma americanum tick. Early symptoms of STARI are similar to early Lyme borreliosis (skin rash resembling Erythema migrans).
In diagnostic of STARI traditional methods are not effective. The decision of antibiotic treatment (similar to Lyme borreliosis) still remain based on clinical picture.
...
And from 2005...
Distribution of Borreliae among ticks collected from eastern states. Taft SC, Miller MK, Wright SM Vector Borne Zoonotic Dis 2005; 5(4):383-9.
Lyme disease is the most commonly reported vector-borne disease in the United States and is transmitted by Borrelia burgdorferi-infected Ixodes species. The disease is typically characterized by an erythema migrans (EM) rash at the site of tick feeding. EM rashes have also been associated with feeding by Amblyomma americanum ticks despite evidence suggesting that they are incompetent vectors for Lyme disease.
In 1996, a Borrelia organism only recently cultivated in the laboratory was described in A. americanum ticks and designated B. lonestari. This Borrelia is believed to be the etiologic agent of a novel Lyme-like disease, southern tick associated rash illness (STARI). This study examined ticks collected from eight eastern states to evaluate the epidemiology of B. lonestari, B. burgdorferi, and their tick hosts.
Three hundred individual or small pool samples were evaluated from tick genera that included Amblyomma, Ixodes, and Dermacentor. DNA was extracted following tick homogenization and the polymerase chain reaction (PCR) was performed using primers derived from the flagellin gene that amplify sequences from both B. burgdorferi and B. lonestari.
Species specific digoxigenin labeled probes were designed and used to differentiate between B. burgdorferi and B. lonestari. Borrelia DNA was detected in approximately 10% of the A. americanum and I. scapularis tick samples, but none was present in any of the Dermacentor samples tested. Positive samples were detected in ticks collected from Kentucky, Maryland, Massachusetts, New Jersey, New York, and Virginia.
This is the first known report of B. lonestari from Massachusetts and New York and the first detection in I. scapularis. This suggests that B. lonestari and its putative association with STARI may be more widespread than previously thought.
...
I realize that conclusions/ findings in these abstracts can be misread if you do not have access to the entire article. Although... to me at least... the text of these conclusions seem pretty definitive?
Please feel free to correct me if I am mistaken.
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bettyg
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part 2 of pam weintraub's memorial article to dr. masters ....
i broke it up and i'm 1st of comments where it's broken up here....
posted
I was told (by a friend of Dr. Masters) his death was from diabetes.
-------------------- Peggy
~ ~ Hope is a powerful medicine. ~ ~ Posts: 2775 | From MN | Registered: Apr 2001
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bettyg
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all 4 parts of dr. masters story, which is all from pam's CURE UNKNOWN BOOK, a complete chapter on him, is now shown on the above link i provided.
just go down thru there and look for parts 3 & 4 to read... **************************************************************
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