“Nobody has been developing drugs against Borrelia, the bacterium that causes Lyme disease,” said Lewis. “Antibiotics to treat this pathogen have been borrowed from other applications, but Borrelia is unique. Its biology is very different, so this borrowing approach from other pathogens is not optimal. We are looking for compounds that specifically hit Borrelia.”
Lewis and members of his lab discovered that there are similarities between Borrelia and other pathogens causing chronic infections: persisters—dormant cells that are highly tolerant of antibiotics. “Conventional antibiotics don’t do much when it comes to killing persisters,” said Lewis. “One of the things we are focusing on is figuring out ways to get rid of persisters.”
Posts: 109 | From The Netherlands | Registered: May 2014
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Like the way he describes stuff. Direct to the point, to the problem, and much nicer than I could say it. HA!
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