"The precise underlying cause of ME/CFS isn't known, although there are a number of theories. Many cases, but not all, seem to develop in the aftermath of an acute infection, for example with the Epstein-Barr virus or other bugs.'"
"The study provides compelling evidence, he says, that the immune system is chronically activated: "As if it's engaged in a long war against a foreign microbe, a war it couldn't completely win and therefore had to continue fighting."
Nath and his co-authors say their findings suggest that something leftover from an infection — an antigen — continues to perturb the immune system. This "chronic antigenic stimulation" triggers a cascade of physiological events that eventually manifest as symptoms."
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