Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
It looks like far infrared (880nm) impacts cytochrome C oxidase which binds to NO...nitric oxide.
Is NO needed to kill Bb...some say NOT:
"Despite being deficient in a key antimicrobial agent, iNOS-deficient mice had tissue levels of B. burgdorferi similar to those in control mice.
Thus, NO does not have a critical role in susceptibility to Lyme arthritis through tissue damage via an overexuberant inflammatory response, nor is it required in resistance through the clearance of spirochetes from tissues."
Now what if we increase Cytochrome C oxidase and lowered/inhibited NO levels?
"Nitric oxide inhibition
increased maternal hematocrit levels
while decreasing maternal erythropoietin levels without significantly altering the maternal acid-base status.
In contrast with chronic hypoxia, nitric oxide inhibition increased fetal NRBCs (Nucleated red blood cells) without affecting erythropoietin levels.
CONCLUSION: Our findings indicate that the number of NRBCs in fetal circulation does not serve as a specific marker of chronic hypoxia that accompanies IUGR or of elevated erythropoietin levels but are an epiphenomenon that is related to the
inhibition of nitric oxide.
Bb's lipoproteins trigger NO...to its advantage perhaps.
Keep this in mind:
"The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the
up-regulation of cytochrome c oxidase,
leading to increased energy metabolism in neurons functionally inactivated by toxins."
A little more complex:
"Pharmacological manipulation of cytochrome c oxidase indicates that this enzyme, when it is in turnover and in its oxidized state,
inactivates physiological amounts of NO,
thus regulating its intra- and extracellular concentrations.
This inactivation is prevented by blocking the enzyme with inhibitors, including NO.
Furthermore, when cells generating low concentrations of NO respire toward hypoxia, the redox state of cytochrome c oxidase changes from oxidized to reduced, leading to a decrease in NO inactivation.
The resultant increase in NO concentration could explain hypoxic vasodilation."
Due to the proximity of the "belly button" to the aorta...placing the far infrared light there maybe very beneficial...it was suggested in one website.
[ 07. June 2008, 07:37 AM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Up...relabeled this to get your attention.
And repeating from another post:
"Factors that trigger osteoarthritis induce the synthesis of nitric oxide by the chondrocytes in articular cartilage.
Nitric oxide levels go up in the joint space, which can sharply increase the biological effects at different levels.
Nitric oxide can act on articular cartilage by
inhibiting the synthesis of collagen
and proteoglycans,
while stimulating the synthesis of metalloproteinases and inducing apoptosis (programmed cell death) of the chondrocytes .
Nitric oxide can act on the synovial tissue by
stimulating the secretion of pro-inflammatory factors into the joint space,
as well as other factors that can
destroy cartilage,
such as the metalloproteinases.
As a result of cartilage destruction, cartilage fragments are released that are also able to induce the release of pro-inflammatory factors into the synovial tissue.
Both IL-1 b AND TNF- a need a mechanism of secondary messengers to perform their functions.
IL-1 b stimulates both the nitric-oxide pathway and the cyclooxygenase 2 pathway, which causes an increase in prostaglandin E2 levels.
Both pathways result in the direct or indirect destruction of the cartilage."
My inquisitive mind is asking:
Does so much COX-2 lower the protective COX-1 levels (they both react with AA)?
[ 07. June 2008, 12:57 PM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
posted
Intersting. My LLMD has be on a NO/ONOO protocol to reduce NO. He says it is causing an 'inflammation cycle' that causes my arthritis to linger.
Posts: 69 | From So Cal | Registered: Jun 2007
| IP: Logged |
troutscout
Frequent Contributor (5K+ posts)
Member # 3121
posted
I take a supplement that increases my NO levels...I have felt better since doing it.
Healthier...more energetic, my circulation seems better also.
-------------------- Now is the time in your life to find the "tiger" within. Let the claws be bared, and Lyme BEWARE!!! www.iowalymedisease.com [/URL] Posts: 5262 | From North East Iowa | Registered: Sep 2002
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic