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» LymeNet Flash » Questions and Discussion » Medical Questions » More on B Vitamin deficiency or B 12 (Page 2)

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Author Topic: More on B Vitamin deficiency or B 12
treepatrol
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Wow Pam!

I jsut wanted to put this weeks update in to. 2/25/2008 doing good otherthan rifampin causing me to wake up through the night no aching at all I have started getting a floater thing in left eye which started about a week into the rifampin Iam glad allmost done with taht stuff.

I feel good sore from all the brooming and shovaling of snow this past week hahaha.

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treepatrol
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Week 3/3/2008 b12 shots doing good shovaled snow friday saturday relaxed sunday sore and today half as sore and gave myself injection this morning feel good!! what a relief after aching for so very very long.!! [Big Grin]

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map1131
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Tree, here's my update. Went to gastro today and he told me all the blood they took doesn't include doing B-12 levels. He said gastritis causes B-12 deficiency. Not lack of B-12 causes gastrisis.

Not a good day today. I'm feeling so defeated at this point. He did order an blood evaluation of my B-12 levels. Didn't have time to get blood drawn this morning. I had appt in 20 minutes with my therpists.

Thank God. I was at the end of my rope this morning. Next step is looking into surgery for hemorrhoids. Problem is nothing has been done to stop the cause of my hemorrhoids. All typical meds have failed at my GI issues that have caused this problem.

I'm glad you keep this thread coming up. I've got to figure something out. Hoorrraaaayyy for Tree.
Shoveled snow? I can't shovel snow due to the other problem? lol

Pam

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treepatrol
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So hang in there and still take b12 shots sometimes I wonder where Drs heads are? [bonk]

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Nicoles Mom
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Nicole is on B-12 shots 2 x weekly. It helps. Her LLMD said she could take as often as every other day.
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treepatrol
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Starting this week 3/10/2008 feel good!!
Still no aching I take one shot 10.ml or 1 cc every four days. [Big Grin]


Had a hemmroid problem better now not completly healed though. [Roll Eyes]

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Ann-OH
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You can get B12 in sublingual pellets at your health food store. I take one called
"No Shot" It has Folic Acid as well. It is pretty inexpensive. I get it for $15 per 90 tabs.

You can read about it here:
http://www.comforthouse.com/nosvitb12.html

A study reported at a Canadian conference said sublingual was as effective as shots. I think I posted that here someplace.

If you want to see it, let me know.

Ann - OH

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treepatrol
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quote:
Originally posted by Ann-OH:
You can get B12 in sublingual pellets at your health food store. I take one called
"No Shot" It has Folic Acid as well. It is pretty inexpensive. I get it for $15 per 90 tabs.

You can read about it here:
http://www.comforthouse.com/nosvitb12.html

A study reported at a Canadian conference said sublingual was as effective as shots. I think I posted that here someplace.

If you want to see it, let me know.

Ann - OH

Thanks Ann
Dont know if it would work on me Iam taking 10ml every for days guess Ill need to convert it to mcg's??

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treepatrol
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Doing good still taking b12 injections every 4th day no more aching!!! yea
Date 3/17/2008

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treepatrol
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Apparently beer flushes b12 I ache today took shot this morning 3/24/08 starting to feel better duh wont do that again.

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treepatrol
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No more beer.

I feel great today. I thoght I better put this link in here easier to find.
B 12 shots whos getting them?

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treepatrol
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Iam feeling good no aching still week of 3/31/08!

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luvs2ride
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Wow! How did this thread get by me for so long?

After treating H. Pylori, my doctor has me on prescription sublingual B-12. It looks and tastes like blood but I am glad to be getting it.

Especially glad after reading this thread.

Luvs

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treepatrol
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Eyes are almost back to normal and the drops worn off almost 40hrs not the same as the eye Drs normal drops.

Anyway feeling great today took b12 shot this morning update 4/4/08

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treepatrol
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I love b12 shots what a difference its making !!

wish I had my intrinsic factor back though.
Date 4/8/08 [Big Grin]

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treepatrol
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4/15/2008
B2 injections feeling stronger each week!!!
No aching at all!!

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sparkle7
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Thanks for all the info.

I get a catalog of vitamins that is geared towards people with fibromyalgia. They sell a bunch of different B-12 supplements.

Do you think any of these are good? Can't really afford shots/doctor at this time.

http://www.prohealth.com/library/powersearch.cfm?searchtext=vit+b-12&x=20&y=11

One of your posts stated that oral supplements (maybe under the tongue) are just as good as shots.

This one seems to cover all the bases -

https://prohealth.com/Shop/product.cfm/product__code/PH314

B-12 Extreme

THE MOST POTENT SINGLE DOSE OF B-12 ON THE MARKET!

ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did! B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide. Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise. Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.

MENTAL ACUITY - Methylcobalamin 12.5 mg
Methylcobalamin, perhaps the most important and potent of the essential cobalamins, plays a vital part in cell growth. Particularly important for your central nervous system, it helps promote healthy homocysteine levels and helps increase the brain's focus and clarity, and the spinal cord's function.


ENERGY - Dibencozide 12.5 mg
Dibencozide metabolizes essential fatty acids to produce more energy. As a biologically active form of B-12, it reacts with cells to provide muscles and nerves with bursts of energy.


LIVER SUPPORT - Cyanocobalamin 7.5 mg
Cyanocobalamin, the most common of the cobalamins, becomes active in your liver, creating enzymes to help the body with blood formation, cell reproduction, iron utilization, and tissue synthesis, while aiding the digestion and absorption of foods.


DETOXIFICATION - Hydroxocobalamin 2.5 mg
Hydroxocobalamin, one of the three essential cobalamins that make up the vitamin B-12 complex, helps remove heavy metals from the system and supports overall detoxification. It also assists with methylation and energy production.


Dissolves under your tongue for maximum absorption.

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treepatrol
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quote:
Originally posted by sparkle7:
Thanks for all the info.

I get a catalog of vitamins that is geared towards people with fibromyalgia. They sell a bunch of different B-12 supplements.

Do you think any of these are good? Can't really afford shots/doctor at this time.

http://www.prohealth.com/library/powersearch.cfm?searchtext=vit+b-12&x=20&y=11

One of your posts stated that oral supplements (maybe under the tongue) are just as good as shots.

This one seems to cover all the bases -

https://prohealth.com/Shop/product.cfm/product__code/PH314

B-12 Extreme

THE MOST POTENT SINGLE DOSE OF B-12 ON THE MARKET!

ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did! B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide. Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise. Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.

MENTAL ACUITY - Methylcobalamin 12.5 mg
Methylcobalamin, perhaps the most important and potent of the essential cobalamins, plays a vital part in cell growth. Particularly important for your central nervous system, it helps promote healthy homocysteine levels and helps increase the brain's focus and clarity, and the spinal cord's function.


ENERGY - Dibencozide 12.5 mg
Dibencozide metabolizes essential fatty acids to produce more energy. As a biologically active form of B-12, it reacts with cells to provide muscles and nerves with bursts of energy.


LIVER SUPPORT - Cyanocobalamin 7.5 mg
Cyanocobalamin, the most common of the cobalamins, becomes active in your liver, creating enzymes to help the body with blood formation, cell reproduction, iron utilization, and tissue synthesis, while aiding the digestion and absorption of foods.


DETOXIFICATION - Hydroxocobalamin 2.5 mg
Hydroxocobalamin, one of the three essential cobalamins that make up the vitamin B-12 complex, helps remove heavy metals from the system and supports overall detoxification. It also assists with methylation and energy production.


Dissolves under your tongue for maximum absorption.

One of your posts stated that oral supplements (maybe under the tongue) are just as good as shots.
I didnt say that someone posted that here but some of the literture does say sublingual is as good as injections.


All i can say is give the b12 sublingual a try and see if it helps. If not then have Dr prescribe b12 injections and give them to yourself I inject myself just between the skin and the fat on my belly at a 10 to 30 degree angle being careful not hitting a blood vessel.

The syringes cost is cheap and so is the b12 juice that you inject.
I know when I tryed sublingual I took 5to10 times the dose but it didnt seem to work at there doses recomended.
That got expensive.
Now the sublinguals you showed me maybe more effcient?

Let me know how it turns out.

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sparkle7
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So happens - I just got this link in an e-mail from Pro-health today (see below) !

Maybe they knew I was checking this info out on their site yesterday???

I got some B-12 at the health food store yesterday & started it right away.

I used to give myself shots of growth hormone - so shots don't freak me out.

I'll ask my doctor!

---
http://www.immunesupport.com/library/showarticle.cfm/id/8730/B1/EP041608Z

Could a Common B-12 Deficiency Be Causing Your Symptoms?

by Dr. Dana Myatt, NMD, and Mark Ziemann, RN*
ImmuneSupport.com

03-08-2008

Advertisement

Less than 20 years ago, patients complaining of fatigue were often given a "tonic shot" by their doctor. Many people claimed this worked like magic to improve their energy levels. What was this miracle tonic? A simple injection of vitamin B-12.
Although the practice of administering vitamin B-12 injections has fallen out of favor, modern medical science now understands why vitamin B-12 supplementation makes people feel better, and the reasons extend far beyond just the "placebo effect" of receiving a shot.

The Far-Reaching Effects of Vitamin B-12 Deficiency

Vitamin B-12, called "cobalamin" because it contains the mineral cobalt, is required for a staggering number of physical functions and chemical reactions. Best known for its participation in the manufacture of red blood cells, B-12 is also needed for production and maintenance of the myelin sheath that surrounds nerves and for production of DNA, the genetic material of all cells. And that's just the beginning.

The serious health consequences of vitamin B-12 deficiency can adversely affect nearly every system in the body.

Energy: Even minor deficiencies of vitamin B-12 can cause anemia, fatigue, shortness of breath and weakness.

The Nervous System: Deficiencies of B-12 can cause neurological changes including numbness and tingling in the hands and feet, balance problems, depression, confusion, poor memory and Alzheimer's-like symptoms. Long-term deficiencies of B-12 can result in permanent impairment of the nervous system.

The Gastro-Intestinal System: B-12 deficiency can cause decreased appetite, constipation, diarrhea or alternating constipation/diarrhea, weight loss and abdominal pain.

The Immune System: Vitamin B-12 is necessary for normal functioning of white blood cells. Studies show that B-12 helps regulate Natural-Killer T-cells and prevents chromosome damage.

The Cardiovascular System: Vitamin B-12 participates in the conversion of homocysteine to methionine. Elevated homocysteine levels are a known independent risk factor for heart attack, stroke and thrombosis. Without adequate B-12 levels, homocysteine levels typically rise.

Special Senses: Degenerative changes in the central nervous system caused by B-12 deficiency can also affect the optic nerve, resulting in blue-yellow color blindness.

Other symptoms of vitamin B-12 deficiency include sore mouth or tongue.

With so many physical functions at risk, it is easy to understand why knowledgeable clinicians and researchers consider B-12 supplementation beneficial.

Are You At Risk for a Vitamin B-12 Deficiency?

Medical science once believed that few people were vitamin B-12 deficient. This false assumption may stem from the fact that vitamin B-12 is produced in the body by a normal, healthy population of bowel bacteria.

Secondly, unlike other water-soluble vitamins, B-12 is stored in the liver, kidneys and other tissues. Deficiencies of B-12 often appear so slowly and subtly as to go unnoticed, and blood tests for vitamin B-12 levels miss early deficiency states at least 50% of the time.

So, who is at risk for vitamin B-12 deficiency? Recent research shows that a much larger segment of the population is likely deficient than previously thought.

Because assimilation of vitamin B-12 from food requires adequate stomach acid and intrinsic factor, and because stomach acid typically declines with age, people over 50 were once thought to be the biggest ``at risk'' population for B-12 deficiency. Previous studies showed 3% - 39% of seniors to be vitamin B-12 deficient, but newer studies suggest that number may be as high as 72% - 78%.

Vegetarians and vegans are another population believed to be at high risk for B-12 deficiency, in part because of low animal food intake of vitamin B-12 and also because many vegetable sources such as seaweed must be consumed in large amounts in order to provide adequate vitamin B-12.

Other high-risk groups for B-12 deficiency include:

Those who use acid-blocking or neutralizing drugs (such as Prilosec, Prevacid, Nexium and others), or drugs which impair intestinal absorption (such as Metformin, Questron and Chloromycetin),
People who have had gastric surgery,
And people who have chronic illnesses such as ME/CFS and Fibromyaligia.
Bacterial overgrowth of the small intestine, which occurs frequently in people with low stomach acid, is a predisposing factor for B-12 deficiency because the bacteria themselves use vitamin B-12.

The most recent and disturbing studies suggest that vitamin B-12 deficiency is more prevalent in young adults than previously thought. One study found that vitamin B-12 deficiency was similar in three age groups (26-49 years, 50-64 years, and 65 years and older), but that early symptoms were simply less apparent in the young.

This study also found that those who did not take a vitamin B-12 containing supplement were twice as likely to be deficient as supplement users, regardless of age.

Four Forms of B-12 - Which One is Best?

Cobalamin is a collective term for four closely related forms of B-12 - cyanocobalamin, methylcobalamin, hydroxycobalamin, and adenosylcobalamin (dibencozide).

Cyanocobalamin, the most common form of B-12 found in nutritional supplements, has the lowest biological activity and must be converted in the liver to methylcobalamin or adenosylcobalamin before it can be utilized.

Because it can be converted to other forms of B-12, cyanocobalamin can be considered the ``mother form'' of B-12. However, this conversion is inefficient and some people may not benefit from cyanocobalamin due to lack of assimilation or conversion.

Methylcobalamin is considered by many researchers to be the most active form of vitamin B-12. It protects the nervous system by regulating glutamate-induced neuronal damage (common in aging) and promoting nerve cell regeneration.

Methylcobalamin is the only form of vitamin B-12 that participates in regulating circadian rhythms (sleep/wake cycles). It has been shown to improve sleep quality and refreshment from sleep, as well as increasing feelings of well-being, concentration and alertness.

Adenosylcobalamin (dibencozide), the second highly active form of vitamin B-12, is essential for energy metabolism. It is required for normal myelin sheath formation and nucleoprotein synthesis. Deficiencies are associated with nerve and spinal cord degeneration.

Hydroxocobalamin is a unique form of B-12 that participates in detoxification, especially cyanide detoxification. Cyanide levels are often elevated in smokers, people who eat cyanide-containing food (like cassava) and those with certain metabolic defects.

Excess cyanide in the tissues blocks conversion of cyanocobalamin to methylcobalamin or adenosylcobalamin. In such instances, hydroxocobalamin may be the vitamin B-12 of choice. Hydroxycobalamin is FDA-approved as a treatment for cyanide poisoning.

Oral Vs. Injectable: Which Delivery System is Preferred?

Although many people including some physicians still believe that injectable vitamin B-12 is the preferred route of administration, it is well-known and widely accepted that oral vitamin B-12 is equally as effective as injection in treating pernicious anemia and other B-12 deficient states.

Conclusions and Recommendations

Vitamin B-12 deficiency is far more widespread than previously thought, with up to 30% of young people affected and possibly as many as 78% of the over 50 population suffering from deficiency.

Those at special risk include:

Seniors,
Vegetarians and vegans,
People taking acid-neutralizing drugs or various other drugs, and
Patients with cognitive impairment and/or chronic illnesses.
The U.S. Institute of Medicine recommends that adults over 50 obtain their vitamin B-12 from supplements.

Because symptoms of vitamin B-12 deficiency often manifest months or years before B-12 blood tests become abnormal, early deficiencies are often missed.

Symptoms and side effects of B-12 deficiency are many and varied, can mimic other diseases such as Chronic Fatigue Syndrome, and can produce irreversible changes of the nervous system if not corrected early.

Oral vitamin B-12 supplementation is extremely safe, as effective as injections, comparatively inexpensive, and more convenient than injections.

Those at risk of vitamin B-12 deficiency or with symptoms suggestive of B-12 deficiency should consider adding this important nutrient to their supplement protocol.

[Note: See also "The Vitamin B-12 - ME/CFS/FM Connection" by Myatt and Ziemann. It explains how two biochemical abnormalities heavily involved in the ``unexplained illnesses'' (ME/CFS, Fibromyalgia, Multiple Sensitivities, Gulf War Syndrome, PTSD) are both related to forms of vitamin B-12 deficiency. The article explains the role of B-12 in: 1) Dr. Martin Pall's model of a dysregulated Nitric Oxide/Peroxynitrite (``No, Oh No!'') cycle, and 2) dysregulation of the Methylation Cycle.]

____
* Dr. Dana Myatt, NMD, is a practicing naturopathic family physician, educator, author, and speaker with a special interest in nutrition. She lectures widely to medical and lay audiences, and hosts a website (http://www.drmyattswellnessclub.com). Mark Ziemann, RN, Dr. Myatt's husband and collaborator, is also an educator, author, and speaker specializing in holistic nursing practice and patient education.

A footnoted version of this article, including 78 reference citations, will be available soon on Immunesupport.com/

___
Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat, or cure any condition, illness, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.

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treepatrol
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sparkle7 Thanks for adding good info!!

I wish I could make everyone see how very important b12 is to the body seeing for me was the very first injection then the studying came.

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treepatrol
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Up for believe3 good luck!!

Iam doing way way way better!!

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treepatrol
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By the way I have stopped all abx's a couple of months now today is 4/24/08.
This is after I did a 16 month straight abx stint.
The way I figure every cell in body is suppose to be replaced in that period 16 months.
After starting b12 shots i have no aching only by the 4th day do i start to ache thats why I get b12 shot on fourth.

Some people it may take more or less b12.

Some b12 may not be the problem but if you have been on abx's a long time I woulkd bet big money your Intrinsic Factor is bad or severly reduced then I promise b12 shots will help!!!

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treepatrol
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Whoops made mistake over past weekend since I havent had any beer for quite sometime .
I had some over weekend and ate a big juicy medium rare stake before bedtime .
Then woke up with Gout in right knee its right up there with lyme joint pain whewwee! [Smile]


I bought some blackcherry extract concentrate and took it every 3 or 4 hrs starting saturday through today monday 5/7/08 and knee is feeling quite alot better.

Anyway this extract sure helped. Now I have been having for the last year or so trouble with higher uric acid problems which brings on gout and people on abx's might use this black cherry extract its about $15.00 at GNC.


Pain is almost all gone at 11am today. This may help you guys?

[ 06. May 2008, 08:08 AM: Message edited by: treepatrol ]

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treepatrol
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From what I gather if your taking cyanocobalamin instead of methylcobalamin then SAMe is needed because in the process of converting in the body cyanocobalamin to methylcobalamin it depletes same.


Appendix: SAMe
Figure 3 shows that S-adenosylmethionine (SAM, aka SAMe) is in the homocysteine-methionine pathway. SAM has been used in the treatment of liver disease, neurological disorders, rheumatoid arthritis,1 and fibromyalgia.2,3 Houston et al.4 noted that SAM is depleted in B12 deficiency. Loehrer et al.1 reported that SAM levels are low in a significant proportion of coronary artery disease patients. Kelly suggests that SAM is involved in converting cyanocobalamin to methylcobalamin.

Loehrer et al.1 showed that 400 mg of SAM (in the form of S-adenosylcobalamin bis(sulfate)-p-toluenesulfonate) taken orally after an overnight fast (with the fast continuing for 6 more hours), caused serum SAM levels to increase substantially, indicating that SAM is absorbed when taken orally. It was well tolerated by all 14 volunteers.

Not enough research has been done to determine whether vegans who have depleted their stores of B12 can benefit from supplementing with SAM in addition to B12. Looking at the biochemical pathways, it would appear that if homocysteine levels are high (which would be expected in B12 deficiency) and folate is adequate, supplementing with B12 would be enough to replenish SAM stores. However, if supplementing with B12 does not resolve symptoms, someone might consider discussing SAM supplementation with their physician.

Notes for SAMe
1. Loehrer FM, Schwab R, Angst CP, Haefeli WE, Fowler B. Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. J Pharmacol Exp Ther. 1997 Aug;282(2):845-50.
2. Jacobsen S, Danneskiold-Samsoe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol. 1991;20(4):294-302.
3. Leventhal LJ. Management of fibromyalgia. Ann Intern Med. 1999 Dec 7;131(11):850-8.
4. Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 1999 Mar;69(3):564-71.
5. Kelly G. The co-enzyme forms of vitamin B12: Toward an understanding of their therapeutic potential. Alt Med Rev. 1997;2(5):459-471.

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treepatrol
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I feel good not gret yet but good!!!
Date: 5/14/2008
I love my b12 shots.

Its to bad everybody thats been on abxs for any length of time do not take this seriously.
What a shame.
Ill see some of you at the finish line.


Ps I want to thank God and Jesus personaly and Publicly here and now!

Thank you lord and father and holy spirit for helping me see what was missing.
And help me to continue to see and know that wisdom and knowledge come from you.
And Love for all these people here on lymenet suffering will gain these gifts.

And thank you for the people that here and see.

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treepatrol
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I just want to bring this up for people who have bad intrinsic factor or have knocked theres out by extended use of abx's.
Get b12 shots ot try high doses of sublingual you will be amazed!!!

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treepatrol
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Up for the lymies

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treepatrol
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up

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Cass A
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Due to this thread, I started taking sublingual vitamin B 12 about 2 weeks ago.

I definitely am less fatigued and have better mental processing!

Thanks for the great info!!

Best,

Cass A

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treepatrol
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Iam glad you were helped !!!
I dont understand why there are not more grasping how much the body needs and requires b12?

Glad you were helped.

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treepatrol
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I still feel pretty good and off abxs but still on probiotics. Date 7/9/08

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Cass A
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I'm curious to know if anyone has tried the "B-12 Extreme" sublingual tablets that have been referenced in this thread.

Here's the data from a previous post here:


https://prohealth.com/Shop/product.cfm/product__code/PH314

B-12 Extreme

THE MOST POTENT SINGLE DOSE OF B-12 ON THE MARKET!

ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did!

B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide.

Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise.

Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.

I'd like to know if anyone has tried it. It's about $50 for a one-month supply, and the doses of each component are in the miligram range, not the microgram range of other sub-linguals.

Best,

Cass A

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treepatrol
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Me to Cass me too
I dont like poking needle in my belly every four days but Iam doing it because it works.

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treepatrol
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up [bonk] [woohoo]

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treepatrol
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Get the b12 people it really really HELPS!!!!

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Mo
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hi tree,

i haven't read the whole thread, but has anyone tried the patch?

supposed to be better than sublingual and to rival injection; little patch worn behind the earlobe for 24 hr period once a week,
at cost of about 25 bucks a month:

http://www.b12patch.com/

i've started it this week.

mo

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treepatrol
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I havent up for answers

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treepatrol
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I wont be around tommorrow so up for the weekenders!!! [Big Grin]

Something that might intrest the people with malaria or babseosis.
catalysT posted this

Vitamin B12 (forms) Anti-Malarial?

Naturally occurring cobalamins have antimalarial activity.


The acquisition of resistance by malaria parasites towards existing antimalarials has necessitated the development of new chemotherapeutic agents. The effect of vitamin B(12) derivatives on the formation of beta-haematin (synthetic haemozoin) was determined under conditions similar to those in the parasitic food vacuole (using chloroquine, a known inhibitor of haemozoin formation for comparison). Adenosylcobalamin (Ado-cbl), methylcobalamin (CH(3)-cbl) and aquocobalamin (H(2)O-cbl) were approximately forty times more effective inhibitors of beta-haematin formation than chloroquine, cyanocobalamin (CN-cbl) was slightly more inhibitory than chloroquine, while dicyanocobinamide had no effect.

It is proposed that the cobalamins exert their inhibitory effect on beta-haematin formation by pi-interactions of their corrin ring with the Fe(III)-protoporphyrin ring and by hydrogen-bonding using their 5,6-dimethylbenzimidazole/ribose/sugar side-chain. The antimalarial activity for the cobalamins (Ado-cbl>CH(3)-cbl>H(2)O-cbl>CN-cbl) was found to be less than that for chloroquine or quinine. Ado-cbl, CH(3)-cbl and CN-cbl do not accumulate in the parasite food vacuole by pH trapping, but H(2)O-cbl does.

Unlike humans, the malaria parasite has only one enzyme that uses cobalamin as a cofactor, namely methionine synthase, which is important for growth and metabolism. Thus cobalamins in very small amounts are necessary for Plasmodium falciparum growth but in larger amounts they display antimalarial properties.

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treepatrol
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For people who have been on abx's for 2 or more years even 5 or 6 like me.
I suggest you get some b12 shots your intrinsic factor may be shot like mine.
Get a shot at your LLMDs next time and watch for changes.
I know the aching dropped way down in me in a about 2 hrs. Enough that I knew this was causing alot of my problems.
Give it a try please!
I have been off abxs since march 08

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treepatrol
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up

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treepatrol
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I'm curious to know if anyone has tried the "B-12 Extreme" sublingual tablets that have been referenced in this thread.

Here's the data from a previous post here:


https://prohealth.com/Shop/product.cfm/product__code/PH314

B-12 Extreme

THE MOST POTENT SINGLE DOSE OF B-12 ON THE MARKET!

ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did!

B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide.

Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise.

Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.

I'd like to know if anyone has tried it. It's about $50 for a one-month supply, and the doses of each component are in the miligram range, not the microgram range of other sub-linguals.

Best,

Cass A

Anyone try these?

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Fordace
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Bump bump........I think I'll try these B-12's....
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seekhelp
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OMG that's a lot of B-12! Very interesting. I'm looking forward to comments as well.
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seekhelp
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FYI, much better price for a limited time. [Smile]

https://www.prohealth.com/shop/product.cfm?product__code=PH314TV

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treepatrol
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quote:
Originally posted by seekhelp:
FYI, much better price for a limited time. [Smile]

https://www.prohealth.com/shop/product.cfm?product__code=PH314TV

Thanks posting that link to sublingual!!! [Big Grin]

Heres one that is buried in the thread;

https://prohealth.com/Shop/product.cfm/product__code/PH314

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treepatrol
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If you have been on abxs for any time after 3 or four months I highly recommend a b12 shot.
At least once a month while treating.
B12 defficiency causes a lot of symptoms that are very Lyme Like!!

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treepatrol
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AliG Biotin Thread

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treepatrol
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upcy daisy

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treepatrol
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[Big Grin]

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kateaton
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Does anyone know the significance of high serum B-12 levels?

My 4 y.o. daughter was tested recently and they came back "sky high" I had them follow-up with a urine methyl malonic acid test, but that came back normal. I still keep thinking that there is some significance to those blood results.

I had heard somewhere that high serum levels can actually mean that it's not getting into the cells. I had her tested because of the dark circles under her eyes and read somewhere of a connection. She also has celiac disease, but she doesn't have any of the other symptoms that were listed for low b12.

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f13girl
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I've been prescribed methycobalmine b12 shots-1000mg/day-does that make sense? does anyone know of a good US source with no chemicals/additives in shotss?
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up
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Remember to Smile
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treepatrol, this is an excellent thread. Thanks for putting together all this info!
Smile

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