I just can't stop picturing big hairy, fury Sherpas lugging Mangosteens in their saddle bags through the likes of South East Asia.
It's all about the humor!!!! Thanks for making me laugh, I needed that.
Elizabeth
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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MartinJS
Unregistered
posted
There's/ nothing funny about bashing other races. Sherpas are an ethnic group from the most mountainous regions of Nepal and are highly regarded as elite mountaineers and experts in their local terrain.
I find the tone of the last two posts extremely offensive. How would you like to be called "Big Hairy Furry American?"
Fist of all Sherpas are neither big nor are they hairy and I do think it time that a moderator put a stop to insulting other races. Enough is enough.
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Perhaps you did not read the whole thread, but these comments stemmed from other comments.
I would never make a racist comment.
I apologize if you are taking it that way.
I was simply picturing Yaks carrying mangosteens in their saddle bags while being hearded by Sherpa's. (It was a silly visual that came to mind) of course the Yak's were the ones that were hairy not the Sherpa's
Perhaps I am dumb as a doorpost, but I seriously must have had an ignorant moment and really thought Sherpa's were hearders of Yaks.
So when Randibear made that stmt. that was the visual that came to mind.
I am very sorry if it was offensive. Please try to understand where I was coming from.
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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I am a very sensitive person and just wanted you to know that it would kill me if I hurt you or anyone else. I was taught that Sherpa's were ppl who carried heavy loads and hearded. See the following definition. I hope this helps to explain.... Thank you for educating me.
"For a foreigner, a Sherpa means someone who carries loads at high altitudes. But Sherpas are actually all Tibetans. They are called 'People from the East. ...
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Or we have to start taking ourselves more seriously. This was not a preemptive American post, Martin. Save the animosity.
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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lymielauren28
Frequent Contributor (1K+ posts)
Member # 13742
posted
I'm sorry but this thread has turned absolutely hilarious to me!! I mean I'm sitting at the computer LMAO!
I'm engaged to a "big hairy furry American"...call me weird but I find him to be quite sexy
So I wouldn't be offended at all by that sort of comment! But that's just me...
Lauren
-------------------- "The only way out is through" Posts: 1434 | From mississippi | Registered: Nov 2007
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
If getting crapped on is funny, then I suppose you're right
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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MartinJS
Unregistered
posted
Elizabeth, thank you for your posts, PM sent.
Unfortunately "Lymeorsomething" needs an attitude-adjustment badly. In Elizabeth's earlier post she said: " I just can't stop picturing big, hairy fury Sherpas lugging Mangosteens in their saddle bags through the likes of Southeast Asia."
Sherpas are no where near Southeast Asia--the Himalayas are north of the Indian subcontinent. Perhaps Lymeorsomething needs a geography lesson along with their AA.
Lymeorsomething, there's nothing funny about flippant remarks about other races/cultures (even inadvertently) over the internet where everyone can see. At least those were the forum rules the last time I looked.
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randibear
Honored Contributor (10K+ posts)
Member # 11290
posted
hey it was most definitely not intended to be offensive.
the term "guys" is an american slang....and i honestly can't remember the name of the animals i've seen in the travel shows.
wow, i am soooo very sorry.
if you think i was rude and offensive, geezzz,,,,
ya'll lighten up...honestly...
ok, i'm done, kaput, over, ....
wow....
of all the people on this board, i'm sure you would realize that to call me down for being offensive is beyond me, simply, beyond me....
-------------------- do not look back when the only course is forward Posts: 12262 | From texas | Registered: Mar 2007
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quote:Originally posted by MartinJS: There's/ nothing funny about bashing other races. Sherpas are an ethnic group from the most mountainous regions of Nepal and are highly regarded as elite mountaineers and experts in their local terrain.
I wasn't bashing them at all! I think they're great!
NMN said something about sherpas harvesting the fruit. Kinda hard when the fruit is grown in Thailand, etc.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96239 | From Texas | Registered: Feb 2001
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
Martin you have selective reading skills. I was referring to the Anti-Americanism of MNM's post. I did not say ONE word about Sherpas.
None of this was started by an American poster.
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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randibear
Honored Contributor (10K+ posts)
Member # 11290
posted
i didn't bring my dog to this fight..
er, i better quit, before lou bans me......
besides, hubbie says when i get angry my accent gets so bad NOBODY can understand me...ya'll.....
-------------------- do not look back when the only course is forward Posts: 12262 | From texas | Registered: Mar 2007
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lymielauren28
Frequent Contributor (1K+ posts)
Member # 13742
posted
Haha Randi! You ought to hear my Southern accent!! I'd probably give you some competition!
Lauren
-------------------- "The only way out is through" Posts: 1434 | From mississippi | Registered: Nov 2007
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lymeloco
Unregistered
posted
You can buy a Mango and get the same results. I myself can't afford the juice, so eat the fruit and get the same result. If you eat what your suppose too, then there is no need for all the supplements you take.
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posted
I agree. The moderators should shut down this post as its getting a bit ridiculous all be it hilarious. LOL
Lymetoo I am well aware of were the fruit is grown I have spent 3 years travelling (mostly in asia and the pacific) and have actually met some sherpas.
I used them in my little imaginary story as they are well known to be the best trekkers in the world.
In hindsight I am not sure they would fancy the heat now that I think about it. LOL
As one person mentioned you really should not take yourselves so seriously. Anti-americanism...pleeeasssee!! Your clutching at straws now. Something tells me you have lived very sheltered life.
I have several family members who are American citizens and I don't think they would see anything that I said as being insulting.
In fact I think they would find it pretty hilarious how up tight you are getting over an over priced juice.
You can look through my posting history and see I commented several times congratulating the US on their appointment of Obama. Don't try deferring away from the topic by trying to paint me as a bigot.
liesandmorelies - Said "One thing to consider is that Mangosteens are not as available as lets say apples and oranges are in the states. In fact in this area it's a much more exotic fruit.
I am currently paying $4 for a half a gallon of orange juice(oranges are very plentiful here). So I really don't think that $17 for 32 ounces is that out of whack when you consider where they are shipping it in from".
I live in Dublin Ireland, I pay about 2 $ for a pineapple that is flown all the way from queensland Australia, Our Kiwis and some apples come from New Zealand etc.
There is no logic in what your saying in this modern era, logisitics has nothing to do with it.
On Xango's website today they are charging 37.50$ per bottle, that is BS admit it.
You are lucky to be able to grow pomegranates in your back garden. Makes it sound even more silly that you would buy mangosteen instead.
Donegal is 5 hours away from Dublin, Geography is probably not your strong point I would guess. Beautiful county, highly recommend a a visit.
I think some of you should take your little linch mob and put it to better use. Like putting pressure on your state politicians about lyme so people can get proper Abx tx, instead of marketing an overpriced bottle of juice.
Like I said. You are boring me now. I would delete this thread but I think there is some great points in it (mostly from me*lol*) and I would like it to be available to others in the search engine.
-------------------- Pos BB and Bart(Q & H IGG pos) Began treat 1 year after start of illness. Diagnosed Feb 2007. Posts: 648 | From Ireland | Registered: Jan 2007
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
NMN, I see you rolled out of bed again. Your points are valid. However, there's no reason to make asinine generalizations about an entire country.
I'm basically a dual Irish citizen so don't make me come back to the old sod and smack you around Dalymount Park
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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luvs2ride
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Member # 8090
posted
I'm married to an irishman and he thinks NMN has been playing too long in the four leaf clovers.
-------------------- When the Power of Love overcomes the Love of Power, there will be Peace. Posts: 3038 | From america | Registered: Oct 2005
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Thank you for insulting me by telling me that I am not logical and that I am silly...
The question isn't what the price of pineapple is in Ireland, it's what the price of a Pineapple would be in Ireland if it were grown in Ireland?????
I made a comparison between oranges which are grown locally and speculated as to the addtional cost of a fruit grown half way around the world, and that would be assuming that demand for each were the same. We both know that the demand for oranges and pineapple for that matter is far greater than Mangosteens, now don't we?????? So, you left out a very important part of the equation, the part about "DEMAND".
Also, in regards to "SUPPLY". Mangosteens are much rarer and can only be grown in very particular situations. There is only a few degrees lattitude from the equator that they can grow and only in particular regions.
PS: I do drink the lovely pomegranite juice too!!!! So who feels silly and illogical now?
PSS: FYI Mangosteen and Mango are a different fruit. I love Mango and it is somewhat available here in California(still somewhat expensive though)
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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Angelica
Unregistered
posted
My DEMAND for fresh mangosteens is huge. If only I had some. They are my all time favorite fruit and I have not had a fresh one as I mentioned before since 2005.
I wonder how well they ship?
I think NMN has a mangosteen juice factory in Asia and this is his strange way of advertising the benefits.
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In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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Angelica
Unregistered
posted
Then again he may not even be in Asia. He could still be hanging around the bogs of Ireland using his neighbors Wi-Fi connection to harass innocent Lymies. You never know.
Maybe he is the Wizard of Peat Bog and we need Toto to expose him either that or we might have to call Interpol pretty soon if my DEMAND for fresh mangosteens gets any worse.
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posted
I think we need to go back to the discussion of hairy, furry Americans. My father was so hirsute that when we were on Fire Island as kids, my friend said my dad looked like he was wearing a mohair sweater with his bathing suit!
Ahhh, sweet memories...
Posts: 345 | From East Coast | Registered: Apr 2008
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Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359
posted
I'm thinking maybe 1/2 pint Mangosteen and a 1/2 pint Guinness...nothing quite like frothy, iron-fortified Guinnosteen. Hell, even NMN would spend $36 for that...
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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posted
Good morning my little Shmangosteen addicts
Angelica your comments gave me a chuckle. It reminded me of someone who has watched "Darby O'Gill and the little people" one too many times and now thinks it is real. Heres a link to bring you back to reality.
As for "harassing innocent Lymies". This is a debate about mangosteen juice (Xango to be precise), so let me remind you that I am suffering as much as the next person with this disease so don't go forgetting that. It does not mean I have to agree with all of you about everything.
And a word of advice. I never refer to myself as a Lymie, In my opinion it empowers the disease and will only have a negative effect on your recovery. I am not a disease and neither are you.
lymeorsomething - I would never mess with the black stuff. Its just fine as it is.
Now I think we can all at least agree on one thing. That Xango charging 37.50 for a bottle of juice that has very little science behind it, is blatant profiteering plain an simple. I want to hear you say it. Just so I know there is at least a shred of sanity left in this forum.
That question was directed at the ones who do not work for Xango of course.
-------------------- Pos BB and Bart(Q & H IGG pos) Began treat 1 year after start of illness. Diagnosed Feb 2007. Posts: 648 | From Ireland | Registered: Jan 2007
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Angelica
Unregistered
posted
My keets are starting to form a swarm due to your overuse of message icons.
Are we all suppose to think the way you do in order to make your world happy because that would be like trying to herd cats and it is not going to happen anytime soon on this forum.
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Rianna
Frequent Contributor (1K+ posts)
Member # 11038
posted
Hey NMN looks like your not gonna be buying the Mangosteen or the Bionic 880 Course then!!!!!!
Mind you like you I probably agree that sticking my head up a Donkies A** would have a better effect than the above mentioned
TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
1: Fitoterapia. 2008 Nov 5. [Epub ahead of print]
Antibacterial Activity of Thai Medicinal Plants against Methicillin-resistant Staphylococcus aureus.Chomnawang MT, Surassmo S, Wongsariya K, Bunyapraphatsara N.
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen which causes severe morbidity and mortality worldwide.
Seventeen Thai medicinal plants were investigated for their activity against MRSA. Garcinia mangostana was identified as the most potent plant, and its activity was traced to the prenylated xanthone, alpha-mangostin (MIC and MBC values of 1.95 and 3.91 microg/ml, respectively).
PMID: 19022354 [PubMed - as supplied by publisher]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
Sorry, I don't have access to full articles.
Medicinal properties of mangosteen (Garcinia mangostana).Pedraza-Chaverri J, C�rdenas-Rodr�guez N, Orozco-Ibarra M, P�rez-Rojas JM.
Facultad de Qu�mica, Departamento de Biolog�a, Universidad Nacional Aut�noma de M�xico, Ciudad Universitaria, 04510 Mexico, DF, Mexico. [email protected]
Many tropical plants have interesting biological activities with potential therapeutic applications.
Garcinia mangostana Linn. (GML) belongs to the family of Guttiferae and is named "the queen of fruits".
It is cultivated in the tropical rainforest of some Southeast Asian nations like Indonesia, Malaysia, Sri Lanka, Philippines, and Thailand.
People in these countries have used the pericarp (peel, rind, hull or ripe) of GML as a traditional medicine for the treatment of abdominal pain, diarrhea, dysentery, infected wound, suppuration, and chronic ulcer.
Experimental studies have demonstrated that extracts of GML have antioxidant, antitumoral, antiallergic, anti-inflammatory, antibacterial, and antiviral activities. The pericarp of GML is a source of xanthones and other bioactive substances.
Prenylated xanthones isolated from GML have been extensively studied; some members of these compounds possess antioxidant, antitumoral, antiallergic, anti-inflammatory, antibacterial, antifungal and antiviral properties.
Xanthones have been isolated from pericarp, whole fruit, heartwood, and leaves. The most studied xanthones are alpha-, beta-, and gamma-mangostins, garcinone E, 8-deoxygartanin, and gartanin.
The aim of this review is to summarize findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far.
PMID: 18725264 [PubMed - in process]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.Balunas MJ, Su B,
Brueggemeier RW, Kinghorn AD. Department of Medicinal Chemistry and Pharmacognosy, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay.
Of these compounds, garcinone D (3), garcinone E (5), alpha-mangostin (8), and gamma-mangostin (9) exhibited dose-dependent inhibitory activity.
In a follow-up cell-based assay using SK-BR-3 breast cancer cells that express high levels of aromatase, the most potent of these four xanthones was gamma-mangostin (9).
Because xanthones may be consumed in substantial amounts from commercially available mangosteen products, the consequences of frequent intake of mangosteen botanical dietary supplements require further investigation to determine their possible role in breast cancer chemoprevention.
PMID: 18558747 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
1: J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9.
Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.Ee GC, Daud S, Izzaddin SA, Rahmani M.
Chemistry Department, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. [email protected]
Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds.
The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone.
Meanwhile, the root bark of the plant furnished six xanthones, namely alpha-mangostin (2), beta-mangostin (3), gamma-mangostin (4), garcinone D (5), mangostanol (6), and gartanin (7).
The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. gamma-Mangostin (4) showed good activity with a very low IC(50) value of 4.7 microg/ml, while alpha-mangostin (2), mangostanol (6), and garcinone D (5) showed significant activities with IC(50) values of 5.5, 9.6, and 3.2 microg/ml, respectively.
This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of alpha-mangostin, mangostanol, and garcinone D against the CEM-SS cell line.
PMID: 18464091 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
Wish I had a copy of the full article on this one. I'd like to know if they can really trace this to the use of mangosteen.
I've seen other articles written about supplements where they claim something caused a problem but when looking at the full history of the patient, it sometimes looks like it could be a number of things that caused the problem.
Not certain as to the accuracy of this but wanted to post it just so those using the juice would be aware.
Am J Kidney Dis. 2008 May;51(5):829-33. Epub 2008 Mar 25.
Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana.Wong LP, Klemmer PJ.
Minor and James Medical, Seattle, WA; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA. [email protected]
The tropical mangosteen fruit has long been prized in Southeast Asia for its traditional healing properties. Mangosteen fruit juice is now available in the United States and marketed for its purported health benefits.
We describe a case of severe lactic acidosis associated with the use of mangosteen juice as a dietary supplement.
PMID: 18436094 [PubMed - indexed for MEDLINE]
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
1: J Toxicol Sci. 2007 Dec;32(5):571-4. Links Inhibitory effects of xanthone on paraquat- and NaNO(2)-induced genotoxicity in cultured cells.Tanaka R.
The inhibitory effects of xanthone on genotoxicity induced by paraquat and NaNO(2) in cultured Chinese hamster lung (CHL) cells were examined.
Xanthone forms the central core of xanthones. Xanthones are present in mangosteen, which is widely used as health food because of its many pharmacological properties.
Paraquat (PQ, a superoxide anion generator) and NaNO(2) induce genotoxic effects, including sister chromatid exchange (SCE) and decreased cell cycle rate, in CHL cells.
Xanthone inhibited the genotoxic effects of PQ and NaNO(2) at concentrations of more than 5 microM. The present results suggested the potent antigenotoxic effects of xanthones in mangosteens.
PMID: 18198487 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
Inflammation is a huge problem for me and for most lyme patients.
Anti-inflammatory activity of mangostins from Garcinia mangostana.Chen LG, Yang LL, Wang CC.
Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, ROC.
The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia.
Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G. mangostana, and both significantly inhibited nitric oxide (NO) and PGE(2) production from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
The IC(50) values for the inhibition of NO production by alpha- and gamma-mangostins were 12.4 and 10.1 microM, respectively. After iNOS enzyme activity was stimulated by LPS for 12 h, treatment with either alpha- or gamma-mangostin at 5 microg/ml (12.2 and 12.6 microM, respectively) for 24 h did not significantly inhibit NO production.
The data show that the inhibitory activities of alpha- and gamma-mangostins are not due to direct inhibition of iNOS enzyme activity. On the other hand, expression of iNOS was inhibited by alpha- and gamma-mangostins in LPS-stimulated RAW 264.7 cells, but not by COX-2.
However, the level of PGE(2) production was reduced by the two xanthones. In an in vivo study, alpha-mangostin significantly inhibited mice carrageenan-induced paw edema.
In conclusion, alpha- and gamma-mangostins from G. mangostana are bioactive substances with anti-inflammatory effects.
PMID: 18029076 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
In my opinion, pro-inflammatory cytokines appear to be a significant issue in lyme patients.
1: Fitoterapia. 2007 Sep;78(6):401-8. Epub 2007 Jun 2.
Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W.
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand. [email protected]
The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties.
P. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne.
Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production.
Houttuynia cordata, Eupatorium odoratum, and Senna alata had a moderate antioxidant effect. In addition,
Garcinia mangostana extracts could reduce the TNF-alpha production as determined by ELISA. Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines.
This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris.
PMID: 17644272 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
This may mean that mangosteen is helpful for babesia!
: Planta Med. 2006 Aug;72(10):912-6. Epub 2006 Aug 10.Links
Prenylated xanthones as potential antiplasmodial substances.
Mahabusarakam W, Kuaha K, Wilairat P, Taylor WC. Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand. [email protected]
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum.
Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity.
Some structure-activity relationships are proposed.
PMID: 16902859 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
I'm not sure but I think xango has the whole fruit. Also don't know how much of certain plant parts one needs to have this type of beneficial effect.
1: Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9.
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A.
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. [email protected]
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential.
Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities.
Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
PMID: 12843596 [PubMed - indexed for MEDLINE]
Posts: 6286 | From Oregon | Registered: Jan 2006
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jamescase20
Unregistered
posted
This is getting sick.
I am checking the scope with mangosteen powder right now...and NO, placing anything on blood DOES NOT KILL IT. Thats like saying placing anything in your morning cup of coffee (and I hope its one cup only-or water instead!) Perhaps cyanide, or maybe rat poison (waferen-not really poison BTW) or honey...and that it dont matter...ANYTHING will sweeten your coffee.
Running of the mouth again I see.
Smear quick check Result: Its only a quick check, so it may not hold much water, but it may debunk the notion that mangosteen is useless.
Smear quick check result: mangosteen placed on known infected blood which had lyme hatchlings in it in anther blood drop 15 mins ago, NO moving invaders, and there appeared to be possible die off due to increased amounts of blood trash in the viewer. I then added a small amount of max oxcide (my trick to pull out hiders still alive from red cells) NO moving invaders found.
"I want to hear you say it. Just so I know there is at least a shred of sanity left in this forum."
WEll, NMN I am sorry for your sake that you believe the only sanity in humanity lies in the hands of those that agree with you. Again talk about "Mesmorized".
It's so cute in a toddler sort of way that you need us so badly to say that the Mangosteen is overpriced.
I just wish I could pinch your little cheek and tell you that it will be okay.
Please, no hard feelings as I think this thread has been beneficial on many levels and heck there has even been some of the best humor thrown in to boot.
Elizabeth
-------------------- aka: Lyme Warrior
In order to do "real" science, you have to have a "real" conversation with nature.
Well Behaved Women Rarely Make History!
"Just Demand your Rights" Posts: 869 | From nor - cal | Registered: Apr 2008
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posted
Okay, I will say it...but I cannot vouch for my sanity! Thirty-seven dollars is a bit overpriced...they have Mangosteen juice in my local store probably for a lot less. (I'll have to check the exact price and report back.)
I, too, hate to see people taken advantage of by folks out to make money off of the ill. But I really don't know anything about Xango except that someone I know did get caught up in the MLM aspect and lost money she could not afford to.
But, if people can afford it, and believe it works for them...it's none of my business. It's small potatoes compared to some of these other expensive, unproven treatments.
I've been trying to make my own fruit smoothies with blueberries, etc., lately because I am not a big fruit eater. I might just add some mangosteen for a fun experiment. (Not Xango, though.)
BTW, I was in Dublin a few years ago and did the marathon there with 18 girlfriends. (I can't even walk around the block now, though). We rented a bus for ourselves and went all around the country...absolutely beautiful. We still all say it was simply the best time we ever had.
Posts: 345 | From East Coast | Registered: Apr 2008
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TerryK
Frequent Contributor (5K+ posts)
Member # 8552
posted
I'm not absolutely positive but I think that most mangosteen products do not have the full fruit like xango does.
Based on the studies that I posted, seems like the full fruit may have benefits that the juice alone does not.
There are many more studies in pubmed than what I posted so I'm not sure why the original poster stated that there is little evidence to support mangosteen.
I'm not saying it is going to solve all your problems but it does have definite benefit for lyme patients as evidenced in some of the research I posted. I do know that my brother got some remarkable benefit from it.
I have never sold one bottle of mangosteen but I have purchased it at $25 per bottle + the cost of membership.
To each his own but when evaluating a product, I like to keep the info factual which includes looking at the research that IS out there.
Terry
Posts: 6286 | From Oregon | Registered: Jan 2006
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Vermont_Lymie
Frequent Contributor (1K+ posts)
Member # 9780
posted
quote:Originally posted by TerryK: This may mean that mangosteen is helpful for babesia!
: Planta Med. 2006 Aug;72(10):912-6. Epub 2006 Aug 10.Links
Prenylated xanthones as potential antiplasmodial substances.
Mahabusarakam W, Kuaha K, Wilairat P, Taylor WC. Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand. [email protected]
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum.
Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity.
Some structure-activity relationships are proposed.
PMID: 16902859 [PubMed - indexed for MEDLINE]
Thanks Terry. You are a great researcher and I always read these abstracts with interest.
Sounds like the mangosteen had "moderate" activity, but their synthetic derivatives were even more "potent" against protozoans. I agree, it could be worth looking into for babesia treatment!
Posts: 2557 | From home | Registered: Aug 2006
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posted
Holy moly people this is nuts!! It's JUICE!! I doubt it cures anything, but it's juice, so it can't be any worse then all the other supplements we take. It doesn't cost anymore then some of the supplements I buy.
So if it helps take it, if not, then move on!!
Kathy
-------------------- You never know how strong you are until being strong is the only choice you have. Posts: 807 | From South Dakota | Registered: Jul 2005
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