LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Mild Hyperbaric Treatment (Page 20)

 - UBBFriend: Email this page to someone!   This topic comprises 91 pages: 1  2  3  ...  17  18  19  20  21  22  23  ...  89  90  91   
Author Topic: Mild Hyperbaric Treatment
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
Thanks Phoiph, I have been aching to talk to you and have tried to PM you twice now... maybe I am not getting through? Lookin' forward to your advice!
Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
foxy loxy...

I double-checked...I haven't received any PM's from you...and my box isn't full...

To PM, click on the envelope icon above this post...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
mbdq
LymeNet Contributor
Member # 26277

Icon 1 posted      Profile for mbdq     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi every one, time for an update! As of yesterday I have reached 600 hours of mHBOT! My health continues to improve, albeit very slowly and with many ups and downs.

Taking some notes every day over the past two years of hbot has really helped to show my improvement. Otherwise, you get up every day and think "My head still hurts, darn that knee is sore again, etc." Overall, the intensity of my symptoms and number of symptoms have reduced. I am leading a very busy and full life.

Its interesting that the topic of emotions came up, as I have been in the THICK of working on emotional issues these past few months. I feel I was holding a lot of emotional trauma and energy in my body. I am working with some great practitioners (EFT, acupuncture, etc) and it has been extremely helpful.

I can tell you that the chamber can be a good, safe place to explore emotions, understand beliefs that are keeping you stuck, and have a good wailing cry!

Overall, mHBOT is my base treatment, along with the GAPS diet and now the energy/acupuncture work. I find the more I work on my gut and really nutrient dense eating, the more positive "bumps" I get. I am not on any herbs or abx specifically for Lyme, but I am using a little bit of Biocidin herbal tincture to try and help my gut out.

I feel I have severe dysbiosis after years of abuse and neglect from 4+ years of abx, birth control pills, stress, sugar, etc.

Its been a long road for me, but I am living and enjoying my life. Prior to finding hbot, I was desperate and had a lot of suicidal ideation because I couldn't see a way out of this mess. And believe me, I spent a lot of money and saw the "best" doc for two years.

I may not be cured, but I am healing. My body still has more work to do and I plan on supporting it any way I can.

We've got quite the group diving now, and I look forward to seeing everyone's progress. We are all going to improve and have many ups/downs at different rates. Try to listen to your body and support yourself.

Hugs to all you brave souls....

Posts: 233 | From Hudson Valley | Registered: Jun 2010  |  IP: Logged | Report this post to a Moderator
Monti
LymeNet Contributor
Member # 45718

Icon 1 posted      Profile for Monti     Send New Private Message       Edit/Delete Post   Reply With Quote 
Mbdq...

Very encouraging post. Thank you!

Posts: 120 | From Maine | Registered: May 2015  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
hi mbdq and phoiph,

I just started on the hyperbaric oxygen

I had one dive last Thursday, one on Saturday and two yesterday
there are two instructors at the facility, on Saturday my first day the lady instructor told me to have the mast on and on her instructions via intercom outside the chamber to then begin tightening the straps of the mask once she turned oxygen pressure on. all was fine throughout the whole session all the way up to maximum [24ft] no problem with blocked ears or any major discomfort

then on my session yesterday the other instructor was on duty and according to his instructions he told me not to tighten the mask straps until he had increased the pressure all the way to maximum
so wile pressure was building up my ears felt very painful and pressurized. as of now 16 hours after coming out of chamber my right ear still hasent popped properly and I feel discomfort

my question is, should I have the oxygen mask on and tightened in place ONCE the pressure is coming through the hose and being increased?

thanks for any help

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi purplehaze...

Would you mind sharing some more information? I have some questions for you to better understand your situation/protocol...

Are you being treated with HBOT for Lyme?

It sounds like you are being treated at a higher pressure than mild hyperbaric (i.e., 24 ft. vs. 11 ft.)...so are you diving at around 1.75ATA?

What kind of mask are you using?

Were you taught different methods to clear your ears?

It also sounds like you're treating more than 1x per day on some days? What is your diving schedule?

About your ear discomfort...

There are several variables that could have contributed.

The second instructor could have pressurized you more rapidly than the first, not giving your ears ample time to adjust.

And/or, you could have had some congestion in your Eustachian tubes on the painful day (which you may not have been aware of) which caused them not to clear properly. This can cause the sensitive tissues to stretch, and cause pain during and after the dive.

You should not experience ear pain in the chamber; pressure is OK, pain is not. If you are having pain, you should alert the operator immediately, and they should depressurize slightly to allow your ears to adjust, and slow the rate of descent.

Did the operator know you were having ear pain?

If you know you have ear congestion, (i.e., from a cold or allergies) which prevents you from clearing your ears, or have any ear pain, you should not dive at all until that has cleared up...

It doesn't sound like the type of mask you're using makes a super tight seal, so don't think having your mask loose during pressurization had anything to do with your ear pain...as it is more a function of the building pressure in the chamber, how fast you are pressurizing, and how well your ears can adjust and clear on that particular day...

(Having the mask loose while pressurizing allows more freedom for clearing the ears via yawning, Valsalva maneuver, opening and closing the mouth, etc.)

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
hi phoiph
thanks for response

to answer your questions

well I was never officially diagnosed with lyme, but all the indications are that I do have it plus possibly/probably co-infections

the hyperbaric centre I am attending are treating all kinds of ailments and probably carry out the same process on patients irrespective of the disease/condition being addressed.

I did tell them that I most likely had chronic late stage Lyme [bitten in 1993] and they said I would need at least 20 sessions/dives

I travel three hour round trip to the facility so that is why I had 2 sessions yesterday and Ive scheduled 2 sessions again this coming Friday and one on Saturday

I wasent aware of any possible congestion on my right ear
incidently now that you mentioned pressure, the first day with the lady operator that particular chamber went down to 24ft [had no issues] but the third day with the guy operator the chamber [different one] went down to 33ft

I did not tell him of the big discomfort with my right ear

yes, but operators explained the clearing of ears process similar to what you have stated here

I don't know the official name of the mask type I was using,
maybe you can view his following link here, there is a guy wearing the mask in one of the photo there

http://www.bhoc.ie/event-press-cuttings/

sorry I cant be any more help

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
Peimomma
LymeNet Contributor
Member # 45177

Icon 1 posted      Profile for Peimomma     Send New Private Message       Edit/Delete Post   Reply With Quote 
Welcome Purplehaze😊. It's great to have new people posting on the board.

Today I thought I would give an update on my husbands progress after 173 dives. He hasn't been tested for Lyme but with all the information about it as an STD he started treated in February as well, just not daily.

I would consider him in very good health at 50, no medication and no illnesses that we know of to date. However we have been monitoring his progress and have seen hair growth, better sleep and he started enjoying reading. He is someone that wouldn't read, in fact I can count on one hand the number of books he's read over the last 9 years. This month he is reading 3 books at one time on different subjects and enjoying them all.

He has also decided to learn a new hobby and signed up for a photography class. It's like the oxygen has awakened his brain.

As for me, this is the first year I'm excited for the holidays in many years. I'm ready to put up decorations, cook big meals and enjoy the company of family and friends.

Posts: 238 | From AZ | Registered: Jan 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi purplehaze...

This is very helpful. I also read about the facility and looked over your other posts on Lymenet to get some background.

Please note that I'm writing this as a non-medical professional, but am basing the information on research I have done, my own experience, many conversations with a neurologist in the HBOT field, and from observing and working with other people doing the treatment.

I'm not giving advice...just relaying what I have learned, and you will have to decide what to do.

There are 2 "camps" on how to treat chronic Lyme with HBOT. One camp is using high pressures (High pressure is greater than 1.5ATA...your 33 foot dive put you at 2ATA), mostly based on a study done years ago that noted that Borellia was killed by high pressures. The problem with the study, is that the lowest pressure threshold to kill Borellia wasn't measured/reported, and so the higher, more risky pressures have been traditionally used. Here's the study:

Effects of Hyperbaric Oxygen Therapy on Lyme Disease: hbotxofpalmbeach.com/study_pdfs/Lyme-Fife.pdf

Treatments under this premise are usually high pressure and done in short term blocks (i.e., 20 or 40 sessions). The problem, aside from greater risk involved, is that I haven't found many people who have had long term success with chronic Lyme from this method. It appears many people cannot tolerate the reaction, and it doesn't address the long term healing of the immune and other systems.

More recent study has shown that neurological conditions are better treated with lower pressures, and that higher pressures over time can actually worsen neurological conditions and be immune suppressive. Chronic Lyme Disease is a neurological condition.

Here's a paper written by Dr. Paul Harch who has been researching HBOT for over 20 years (I would also consider reading his book, "The Oxygen Revolution"):

More is Better: The Recurrent Illusion of Higher Pressure HBOT in Chronic Brain Injury, by Dr. Paul Harch: http://www.netnet.net/mums/Harch2.htm

As I have written many times, the way I became well is through consistent, 1 hour, daily, mild pressure treatments (via home chamber with supplemental oxygen) over a span of time.

Oxygen is a drug...and it produces free radicals which are beneficial against pathogens. When oxygen is done under pressure, the body produces its own extra antioxidants to "mop up" the free radicals after they have done their job.

A balance must be struck; if someone who is already in a compromised state of health via chronic illness does high pressure treatments (especially multiple times per day), they might not only experience significant reaction from the die off, but also oxidative stress, as their bodies may not be able to produce enough antioxidants to "mop up" the free radical load. (Taking artificial/supplemental antioxidants doesn't solve this issue.)

The high pressure, short term therapy which focuses on "killing the bugs", also doesn't take advantage of the most important long term HEALING effects of mild hyperbaric...(e.g., modulating/empowering the immune system, regenerating neural tissue, mobilization of stem cells over time, etc.)

The concerns I have in your case are the random, high pressures/depths being used, the multiple treatments per day, the short term nature of the therapy (although you wouldn't want to do long term, high pressure therapy due to risks), your ear current ear pain, and whether or not someone knowledgeable is following your case.

Another concern is whether you are taking anti-microbials or other therapies that may interact or the effects to be potentiated or reduced by the high pressure treatments.

I'm not trying to discourage you at all...on the contrary...just concerned about the method, as hyperbaric is a powerful treatment, and is often underestimated, particularly when treating chronic illnesses...

Please feel free to PM me also...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
hi phoiph,
many thanks for your great reply
after reading through all your message and the link provided, I said to myself "here we go again" its so typical of this sphere of chronic infection and treatments/remedies that it would have to come down to major ambiguity as to how one should go about solving this puzzle.

I think the facility I'm attending are definitely going on the principle of "more is better" because there are two chambers there [one at 24ft and one at 33ft] and judging on the little info they have imparted to me I will be treated inside the 33ft one
this leaves me in quite the predicament

I had planned on treatment tomorrow [double session] and one on Saturday but after explaining my ear discomfort issue to the main administrator/operator she said I should stop for now and get doctor prescription for antibiotics as it may be latent/lingering ear infection I'm dealing with

right now I'm not taking antimicrobials, but am doing the MMS protocol [started in July this year] plus Essiac tea, Magnesium oil and supplements [B6, zinc, copper]

will keep you posted....

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
purplehaze...

I know, I know...it is so discouraging and exhausting to have to fight through all the different information, opinions, methodologies, etc.

If you wanted to continue to dive at this facility, they likely could adjust the pressure/depth to no more than 16 ft., which would still be mild pressure (approximately 1.5 ATA). (It does sound like this is a community facility though, and I would guess coordination of other schedules would be necessary so members were diving at the same depth at the same time...)

The distance issue remains; how do you dive daily when the facility is a 3 hour round trip, not counting the time spent in the chamber?

This is not only a dilemma in Ireland (at least Ireland has such facilities!)...it is the same here, with the additional expense per dive in a clinical setting.

The other option would be to purchase or rent a home chamber...as many here have done...and/or share expenses with others in close proximity who need treatment and could use it cooperatively.

If you are interested in doing this, I can connect you with a liaison that handles chamber purchases or rentals overseas...you can PM me for more info.

I hope you don't give up on this therapy. Where there's a will, there's a way...

As for your ear, I agree that you shouldn't dive again until it is better. It may not be an infection, however,...they could've just pressurized you too quickly, which stretches the delicate membranes and can cause soreness...so be sure to discuss this possibility with the doctor...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
Haley
Frequent Contributor (1K+ posts)
Member # 22008

Icon 1 posted      Profile for Haley     Send New Private Message       Edit/Delete Post   Reply With Quote 
Purplehaze . I had the same experience when I first dove. I had so much pain in my right ear that I thought I had busted my eardrum. I have had a low grade infection on the right side of my throat/ear for a long time. So based on my experience , it will exasperate an infection if there is one. I agree that lower pressure would be better until the pain is under control.

I continued to dive and the pain is mostly gone now. I'm still not well , but continue to dive.

Best of luck in your mhbot journey.

Posts: 2232 | From USA | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
Haley,
thank you for wishes

well that is interesting you had very similar situation,
I will take antibiotics [if doc prescribes them] and see if that helps to handle this issue.
then hopefully I can resume the hbot asap

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
peimomma,

wow, 173 - that is some serious diving

glad you and hubby are doing well, and its really encouraging to hear results like these are achieved by people doing the hbot

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
hi phoiph

my pm to you was rejected, your inbox is full

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Apologies, purplehaze!

Should be OK now...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
soccermama
LymeNet Contributor
Member # 35101

Icon 1 posted      Profile for soccermama     Send New Private Message       Edit/Delete Post   Reply With Quote 
I'm super stoked. I have been watching this thread for some time and like all of you have tried so many different things to restore my health.

While I believed that Mhbot was beneficial, I just couldn't seem to justify the cost after having wasted my money on so many things. Finally, my husband said, "we just need to do it."

I contacted Phoiph but I had a problem. I had not seen my LLMD since February. I had scheduled an appointment with a functional medicine doctor but couldn't get an appointment until February.

Anyway, my husband called my old LLMD for me and asked for the prescription and I got it in the mail yesterday. I can now move forward.

Now we just have to go through the process of purchasing one. Since we will have to finance, we may wait until January for tax purposes but it is going to happen.

Yeah!

Posts: 538 | From kentucky | Registered: Nov 2011  |  IP: Logged | Report this post to a Moderator
Monti
LymeNet Contributor
Member # 45718

Icon 1 posted      Profile for Monti     Send New Private Message       Edit/Delete Post   Reply With Quote 
Wonderful!! I hope this makes all the difference for you!!
Posts: 120 | From Maine | Registered: May 2015  |  IP: Logged | Report this post to a Moderator
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
Man, I feel like I am back on IV rocephin on mild hyperbaric if I do to much. Brings on neuro head jazz... yuckers!! Phoiph helped me cut way back and so far I seem to be going back to my normal cruddy head. Dive away friends! [Smile] anxious to see how you all continue to do as well! Go soccermama!
Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
jarjar
LymeNet Contributor
Member # 8847

Icon 1 posted      Profile for jarjar     Send New Private Message       Edit/Delete Post   Reply With Quote 
Just a quick update on my experience with mhbot. I have been diving daily for about 1 1/2 years 1 hour daily. My feelings are the same about this therapy.

I have NO regrets buying a used Oxyhealth chamber as I function better with the daily diving and can tell a difference when I skip a day. I find diving not a silver bullet for me but a tool along with my gb4000 with MOPA (rife machine) to be able to function better.

Also diet plays a major roll with me. No gluten, low fat and sugar free (use a little stevia for substitute when needed).

I remember phoip saying she was really careful with her diet and was big on bone broth during her healing best of my memory.

Posts: 805 | From Utopia | Registered: Feb 2006  |  IP: Logged | Report this post to a Moderator
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
jar, jar, I am too lazy to see if you posted earlier...how much help have you find hbot to be and how bad were you? Thanks for posting!
Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
toyswalk
Member
Member # 45981

Icon 1 posted      Profile for toyswalk     Send New Private Message       Edit/Delete Post   Reply With Quote 
Just completed my first home dive!

I have major mobility issues so getting me out was a real challenge. But, as I've told friends, we managed to do it without calling the fire department or filing for a divorce! Hopefully we learned a few things and it will be easier tomorrow.

Posts: 42 | From beautiful Texas Hill Country | Registered: Jun 2015  |  IP: Logged | Report this post to a Moderator
soccermama
LymeNet Contributor
Member # 35101

Icon 1 posted      Profile for soccermama     Send New Private Message       Edit/Delete Post   Reply With Quote 
Phoiph,

Wanted to ask this question on the public forum so all can benefit. When I spoke with you about which chamber to get you spoke about the difference between the vitaeris and respiro.

I know the size is the biggest difference but you also mentioned something about the compressor, I think.

Also, do we have to get a bigger concentrator or will the Airsep 10L work?

We qualified for a loan so it looks like we might be able to purchase a unit outright depending on the cost.

Thanks for the help!

Also, do we have to get a bigger

Posts: 538 | From kentucky | Registered: Nov 2011  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi Soccermama...

Just to clarify...

The compressor is what is used to pressurize the chamber with room air.

The oxygen concentrator takes room air and removes nitrogen, concentrating the oxygen. This is the oxygen source that is breathed through the mask, and has little to do with pressurizing the chamber.

The Vitaeris (larger chamber) comes with a larger compressor, so it can fill faster (sometimes with older chambers, 2 smaller compressors are hooked together). The Respiro (medium chamber) comes with a smaller compressor.

Both chambers (plus the Solace, the smallest chamber) reach the same pressure (4.2 PSI, or 1.3 ATA); the main difference between them is the size.

The oxygen concentrator that is used with any of the chambers must supply sufficient PSI (pounds per square inch) to counteract the backpressure from the chamber. The Airsep you mention has 20PSI, which is plenty, as it well exceeds the 4.2 PSI of the chambers.

The LPM (liters per minute) refers to the how many liters per minute of oxygen the concentrator can supply. In this case 10...but with the AirSep, it is important to set it at 8.5 when using it with a chamber (no higher). This is because the backpressure from the chamber will make any concentrator work harder, and this model will go into a protective "on demand" mode (instead of continuous flow) if set higher (to preserve oxygen purity). Setting it at 8.5 will avoid this, and still provide plenty of 02.

Hope this wasn't "too much information"... [Smile]

To summarize...your Airsep 20PSI 10LPM concentrator will work great for any size home chamber, and is the best choice in my opinion...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
Marnie
Frequent Contributor (5K+ posts)
Member # 773

Icon 1 posted      Profile for Marnie     Send New Private Message       Edit/Delete Post   Reply With Quote 
I need some expert opinions - am I on the right track?

If you plow your way thru this, I guarantee you will be amazed by some of the information.

I think Bb is very similar to the following pathogen (which is PHOTOSYNTHETIC):

The phototrophic bacterium Rhodobacter capsulatus contains a single,

oxygen-responsive superoxide dismutase (SODRc) homologous to iron-containing superoxide dismutase enzymes.

Recombinant SODRc, however, displayed higher activity after refolding with Mn2+, especially when the pH of the assay mixture was raised.

SODRc isolated from Rhodobacter cells also

***preferentially contains manganese,***

but metal discrimination depends on the culture conditions, with ***iron fractions increasing from 7% in aerobic cultures*** up to 40% in photosynthetic cultures.

Therefore, SODRc behaves as a Mn-containing dismutase with cambialistic properties.

Rhodobacter capsulatus is a gram-negative phototrophic bacterium that can thrive under a broad range of environmental conditions.

When the *oxygen tension is low*, these microorganisms *synthesize ATP through a light-driven, anoxygenic electron transport* around a single photosystem

whereas in the presence of air

they shift to a

respiratory metabolism

after ***expression of oxidases and dehydrogenases.***

http://jb.asm.org/content/185/10/3223.full


NADH ***oxidases*** from Borrelia burgdorferi and glyceraldehyde-3-phosphate ***dehydrogenase*** (GAPDH) in Borrelia burgdorferi…

”Oxygen is key to the phagocytosis and killing of bacteria by neutrophils or polymorphonuclear cells (PMNs).

This process involves the production of oxygen radicals and superoxides and is directly influenced by the oxygen concentration in the tissue.

As the oxygen tension falls below 30 mmHg the efficiency of bacteriocidal action of PMNs begins to drop off dramatically.

This was demonstrated by Knighton et al in 1984 where the phagocytic activity of neutrophils in ingesting Staph. aureus was compared to oxygen tension.

http://tinyurl.com/h6d4a8b

One of the reasons why I believe Bb is "photosynthetic" has to do with the potential of the Western Fence Lizard to completely destroy Bb.

And like the other pathogen mentioned earlier, Bb appears to be influenced by oxygen tension levels

- preferring low oxygen tension

to make ATP through a light-driven, *anoxygenic* electron transport.

For newbies...that lizard has a pineal gland on top of its head. It also has a BLUE (cyan) belly. It hunts for food at night (insects)and has to be able to see in darkness i.e., HAS to have a lot of eye rods. Thus it can capture ANY available light (moon light, star light)in order to see its prey.

While hunting, the WFL is covered with Bb infected ticks, but when they fall off, they no longer contain any Bb.

It is believed the WFL has an enzyme (destroyed if the blood is heated) that is protective and is capable of destroying Bb. When the WFL's blood was heated and Bb was re-introduced, Bb survived. So heat, destroyed a beneficial protein.

But...

Light inactivates this enzyme:

AANAT is rapidly *inactivated* when animals are exposed to light at night.

It causes serotonin -> melatonin.

IS THE PROTECTIVE PROTEIN ACTUALLY SEROTONIN?

We KNOW serotonin levels are low in lyme:

http://tinyurl.com/zkdpqr4

And...


The data indicate a role of the immune system and particularly of endogenously formed cytokines, like

interferon-gamma and tumour necrosis factor-alpha, effecting tryptophan

and neopterin metabolism in patients with acute Lyme neuroborreliosis.

PMID: 7865624

AND...HBOT therapy - serotonin:


whereas in the subgroup treated with HBO2 the clinical effectiveness and the appearance of plateau in the binding curves indicated that the oxygen therapy could act through serotonergic pathways.


PMID: 9171470


While Bb is very tryptophan dependent...

does forcing the tryptophan -> serotonin "direction" (but inhibiting melatonin production)

rather than

using IDO (enzyme) which helps tryptophan -> KYN (elevated in MS, HIV, etc.) and ultimately to niacin...

"do in" Bb?

Does light inactivate IDO? (Remember, we BLINK)

Keep in mind....as the sun rises...melatonin gets converted BACK to serotonin and of course we also need to make niacin via tryptophan w/ IDO route.

The reverse process begins to happen as the sun sets (serotonin -> melatonin).

How important is it to INACTIVATE IDO?

Cancer...

Taken together, our findings support the suitability of d-1-methyl-tryptophan for human trials aiming to assess

the utility of IDO inhibition to block host-mediated immunosuppression and enhance antitumor immunity

in the setting of combined chemo-immunotherapy regimens.

http://cancerres.aacrjournals.org/content/67/2/792.full

Sidenote: my sis (now autoimmune from lyme) looks to have prevented "neuro" lyme via taking the highest level of Prozac allowed.

This is very complex because Bb needs norepinephrine and epinephrine and locks onto them. Prozac increases norepinephrine, but it also

increases serotonin.

So while it does appear HBO therapy (esp. in conjunction with abx.) can clear Bb, I think the use of light frequencies (Hz) - very specifically 432Hz (perfect A, the frequency of light) with a binaural beat of 8Hz - can also be very useful.

8Hz is very unique...it is the frequency between theta and alpha brain waves, supposedly the bridge between consciousness and subconsciousness.

It is also the frequency of ...get this...hydrogen. 432 Hz resonates with a frequency of 8 Hz (which corresponds to the note "C")

8 Hz is the resonant frequency of 432 Hz (the frequency of light) and is the resonant frequency of hydrogen AND

is the frequency of the double helix in DNA needed for replication!

How does HBOT relate to DNA?

MECHANISMS OF ACTION FOR BENEFIT OF HBOT:

Promotion of DNA transcription and DNA signaling

More here:

http://drcranton.com/hbo.htm

For HBOT researchers - a book:

http://webcache.googleusercontent.com/search?q=cache:srhqOp2hB7IJ:http://www.hbot.com/the-oxygen-revolution-book-endorsements

I love the reviews from others in support of the above book! Tremendous "insight".

As an adjunct to HBOT, consider listening to this CD (WITH HEADPHONES):

http://www.amazon.com/Chakra-Healing-432-Binaural-Beats/dp/B00K043G6Q

I believe a cure IS possible and I believe sharing knowledge and experiences will eventually -> a cure for all.

God Bless.

Posts: 9481 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
susank
Frequent Contributor (1K+ posts)
Member # 22150

Icon 1 posted      Profile for susank     Send New Private Message       Edit/Delete Post   Reply With Quote 
I'm interested and have questions.
Thanks to all that post here with your experiences and your words/offers of help.

I looked into mHBOT about a year ago - tried to find a place near me to try a few dives.

I remember reading something about a side effect of cataracts? That scared me off a bit.

Thoughts/questions about a home unit:

I am extremely chemical sensitive - do the units smell? The portable units are a kind of fabric?

The system is the chamber, oxygen of some kind and a compressor? My ears are so sound sensitive - wondering if I could tolerate the noise?

I have head pressure and recently eye pressure (an eye herx from Rocephin?). Also allergies and/or respiratory infections* and am usually congested. My right ear seems to always feel congested. A no-go for mHBOT?

*I have the immune deficiency CVID - which means respiratory issues. I just started seeing an allergist/new immuno about allergies and IVIG/SCIG. (I do SubQ Gamma).

It's a problem having CVID and Lyme - I always feel bad - but cannot tell if I am having alleriges, a cold/flu or a bacterial respiratory infection.

A poster on this thread brought up the subject of Lymie's not getting colds. I had forgotten about that.

Also some folks that have an ID don't show the outward symptoms - like lots of sneezing and coughing.

I am gearing up to see the allergist/immuno for a follow-up next week. I told him I have Lyme and he did not poo-poo that at all.

When I saw him my eyes were in bad shape - blepharitis. He made a comment that with my ID my immune system might not make the "pus" commonly seen in people with healthy immune systems that excrete copious amount of yellowish pus when they have blepharitis/conjuncitivis.

I thought that was interesting. He also mentioned the inflammation in the eye was from the toxins the bacteria secretes.

I went to see him thinking allergies - because of clear thick discharge from my eyes.

Point: Atypical symptoms presenting when one has Lyme and/or CVID.

I have not had a cold in years - since Lyme Dx. Or maybe I have had one - just feel awful - but no sneezing. Because my immune system is not mounting a response?

So.......mHBOT is helping folks with their immune system and Lyme?

Curious if doing mHBOT for Lyme would help with other infections?

Sorry have written so much - when I get tired - I get wordy..........

I am seriously thinking about trying then buying a unit for myself. If it is not too loud and chemical smelling. And if I can figure out why I have nasal and ear congestion. As no mHBOT with ear congestion, right?

--------------------
Pos.Bb culture 2012
Labcorp - no bands ever
Igenex - Neg. 4 times
With overall bands:
IGM 18,28,41,66 IND: 23-25,34,39
IGG 41,58 IND: 39
Bart H IGG 40

Posts: 1613 | From Texas | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
Marnie
Frequent Contributor (5K+ posts)
Member # 773

Icon 1 posted      Profile for Marnie     Send New Private Message       Edit/Delete Post   Reply With Quote 
Undermethylated-high histamine.

Genetically and/or pathogen triggered.

Due to your respiratory issues, HBOT may be too risky for you.

That's not to say you can't go a different route...Rife.

A very healthy diet and exercise (AS TOLERATED!) is important too.

Listening (with headphones) to the CD I linked (not expensive) may help too.

If serotonin IS the key (and I believe it is - read my post yesterday - 12/8)...we may have a problem systemically.

Excess serotonin in the gut = N/V. Zofran blocks it.

If Bb is in the gut...we desperately need Tritec (Rantinidine Bismuth Citrate) which rids all forms of Bb in the gut...all forms.

Rantinidine is Zantac. Bismuth citrate is NOT Pepto Bismol.

I believe Tritec is still available in Europe and could certainly be compounded in the U.S. with a prescription from a doctor.

Oddly...a lot of serotonin is made in the area of the bowel where our appendix is.

Skim this abstract (appendix-serotonin) here:

http://www.ncbi.nlm.nih.gov/pubmed/19132991

The above will give you insight re: serotonin-inflammation.

I've said over and over...we have to tame down inflammation AND hit Bb.

Posts: 9481 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
susanK...

To answer some of your questions...

--Maturing of pre-existing cataracts and myopia (usually reversible) is more of a risk with higher pressures and 100% medical grade oxygen as often used in clinical settings, but have not been associated with the lower pressures used with home chambers.

--New chambers, masks, and tubing do smell and can be effectively off-gassed for sensitive people. Used chambers are available, as are ceramic and stainless steel masks.

--The compressor and oxygen concentrator do make noise, but there is a sound dampener inside the chamber, and it is more of a "white noise" inside. Once up to pressure, you can wear noise-cancelling headphones if necessary.

--Yes, one of the many benefits of mHBOT is to increase and modulate the immune response, as well as release stem cells. By normalizing the body's immune response, it has a broad effect. It also has a direct effect on pathogens, inflammation, hypoperfusion, etc.

--You must be able to clear your ears to equalize the pressure when "diving". If you have congestion that prevents this, you must either wait until it clears, or if it is chronic, there are other methods people have used successfully. It becomes less of an issue for most people as they do more mHBOT.

--You will need a prescription/clearance from your doctor to buy a chamber. I would also suggest doing a few sessions first to learn how to clear your ears and see how your ears adjust.

If you PM me, I will give you information on possible locations near you where you can do a few sessions, and also information on options and discounts for renting or buying a home chamber, etc.

I also have lots of resources for you to read, if you like. A good starting point is "The Oxygen Revolution", by Dr. Paul Harch. Also, here is a link to a short, animated video that describes how hyperbaric oxygen therapy works in general:

http://www.youtube.com/watch?v=wcSQQCzi1yg

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
JCarlhelp
LymeNet Contributor
Member # 15957

Icon 1 posted      Profile for JCarlhelp     Send New Private Message       Edit/Delete Post   Reply With Quote 
I know when my wife was doing HBOT and felt at all stuffy she would take Claritan about 30 minutes before dive.
Posts: 366 | From Kalamazoo, Michigan | Registered: Jun 2008  |  IP: Logged | Report this post to a Moderator
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
Did anyone notice Excessive dreaming on mHBOT? or am I crazy??? I mean every night since...
Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
The way I understand it, more REM (dream-state) sleep is a sign that your brain has access to more oxygen...and cerebral blood flow...

REM sleep burns more fuel (oxygen/glucose), and there has to be enough fuel "on board" to attain this state:

"...REM sleep time is strongly reduced by hypoxic and increased by hyperoxic atmosphere, in accordance with the existence of an O2 diffusion limitation. Any pathological decrease in arterial PO2 and/or O2 delivery creates a specific risk in REM sleep..."

http://www.ncbi.nlm.nih.gov/pubmed/11382905

I remember lots of bizarre brain "trips" (both awake and during sleep) as my brain was awakening and knitting back together. I would have phases of enhanced creativity and imagination, as well as memories I hadn't recalled in decades. Then, this state would "normalize", and another phase would begin.

In retrospect, it makes sense that the circuits were being reconnected...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
purplehaze
Member
Member # 40385

Icon 1 posted      Profile for purplehaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
well I've never had a problem with dreaming over the last several years, I mean I tend to dream a lot, its actually quite exhilarating and many times I go to bed thinking - "hmm I wonder what am I gonna dream about tonight" as though looking forward to it..
since starting the HBOT I haven't noticed dreaming any more than usual

Posts: 69 | From Ireland | Registered: Apr 2013  |  IP: Logged | Report this post to a Moderator
Marnie
Frequent Contributor (5K+ posts)
Member # 773

Icon 1 posted      Profile for Marnie     Send New Private Message       Edit/Delete Post   Reply With Quote 
There is a great deal of evidence that acetylcholine is associated with REM sleep.

For example,

release of ACh in the cortex is highest during waking and REM sleep,

and

lowest during delta sleep.

Further, drugs that act as ACh agonists increase REM, and

antagonists decrease REM.

http://webcache.googleusercontent.com/search?q=cache:ORYUsxkBVNMJ:http://web.mst.edu/~rhall/neuroscience/03_sleep/sleepneuro.pdf

More benefits of HBOT:

Plasma AOPP (advanced oxidation protein products ) levels were lowered significantly

after fifteen consecutive HBOT sessions (between-day variations).

***Decreased AOPP levels*** suggest that increased oxygenation of tissues due to HBO therapy may activate some endogenous
factors that prevent hazardous effects of the disease itself.

http://www.ncbi.nlm.nih.gov/pubmed/16787595

Advanced oxidation protein products (AOPP) are defined as

***dityrosine containing cross-linked protein products***

and are reflect oxidized protein damage.

AOPP has been used extensively as biomarkers of inflammation and oxidative stress.

Several studies have been shown that AOPP levels are increased in many pathological conditions such as diabetes mellitus, chronic kidney disease, coronary artery disease, Behçet's disease.

http://webcache.googleusercontent.com/search?q=cache:3nnITVjdqJoJ:http://www.jns.dergisi.org/text.php3%3Fid%3D682

Results also revealed the prevalence of dityrosine crosslinks in amyloid plaques in brain tissue and in cerebrospinal fluid from AD patients.

Aβ dimers may be stabilized by dityrosine crosslinking.

These results indicate that dityrosine cross-links may play an important role in the pathogenesis of Alzheimer’s disease and

can be generated by reactive oxygen species

***catalyzed by Cu2+ ions.***


The observation of increased Aβ and dityrosine in CSF from AD patients suggests that this could be used as a potential biomarker of oxidative stress in AD.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880074/

Copper:

However, TMA studies have revealed that tissue copper levels are

above normal in patients with osteoarthritis.

This can be explained by the calcium-copper-vitamin D relationship discussed later.

Generally speaking, we find that

copper deficiency causes a disturbance in cellular
immunity,

while copper excess causes a disturbance in

humoral immunity." = Th2.

http://webcache.googleusercontent.com/search?q=cache:w52nZ4jMR_oJ:http://www.traceelements.com/Docs/The%2520Nutritional%2520Relationships%2520of%2520Copper.pdf

(Sidenote: Wilson's disease = bipolar trigger is caused by high copper levels. Genetic transporter problem -> AD.)

Humoral immunity, also called the ***antibody-mediated*** beta cellularis immune system.

Humoral immunity refers to antibody production and the accessory processes that accompany it, including:

Th2 activation and cytokine production,

germinal center formation and isotype switching, affinity maturation and

memory cell generation.

Wikipedia.

Zn-Cu balance...Zinc down, copper up.

NORMALLY women have more copper than zinc (men the opposite) because it is used to make an enzyme called

DAO which blocks histamine in foods (H2).

That enzyme goes up a LOT (!!!) during pregnancy because excess histamine is toxic to a fetus.

Tritec to rid all forms of Bb in the gut contains rantinidine (= Zantac = H2 blocker) + bismuth citrate (is NOT Peptol Bismol)

A really good link follows:

http://www.positivehealth.com/article/skincare/atopic-eczema-help-for-sufferers

Generally speaking Bb's OspA triggers IFN-A not IFN y (interferon alpha, not interferon gamma).

"If an invader triggers a TH1 immune response then these molecules are predominantly triggered:

• Interluken-2 (IL-2), Interluken 12 (Il-12) , gamma interferon (IFN-gamma) and IgA (Immunoglobulin type A), amongst others;

For a predominantly TH2 immune response, these molecules are activated for defence:

• Interlukens (IL)4, 5, 6, 10, alpha interferon (IFN-alpha), IgE (Immunoglobulin type E) and IgG.

See where our first response to Bb was Th2 via IFNa and not IFNy = Th1?

Ascorbic acid lowers Cu. Timed release vitamin C (in gelatin capsules) may help. NOT Na + vitamin C. If zinc is low and copper is high, to restore a balance we need to raise zinc and lower copper.

Remember how that is the "formula" Zn+ vit C to help prevent colds (viruses)?

A Novel ***Copper Chelate*** Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells

The use of the product mentioned above ->

"not only allowed strong Th1 response marked by generation of ***high levels of IFN-γ*** but also reduced activation induced T cell death."

"Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers through reprogramming of TAMs that in turn

reprogram the T cells and reeducate the T helper function to

elicit proper anti-tumorogenic Th1 response

leading to effective reduction in tumor growth."

http://webcache.googleusercontent.com/search?q=cache:TUMGRYU6fooJ:http://journals.plos.org/plosone/article%3Fid%3D10.1371/journal.pone.0007048

If you've followed my serotonin links...

These results imply that

copper reduces N-acetyltransferase activity,

which results in a

***decrease in N-acetyl serotonin synthesis.***

But...

Melatonin when coadministered with copper appears to

prevent the N-acetyltransferase inhibition by copper.

Copper exerts contradictory effects on 5-methoxytryptophol synthesis.

Further investigations need to be carried out to examine the effects of copper on the pineal enzymes.

http://www.ncbi.nlm.nih.gov/pubmed/11769332

The substrates for IDO (the enzyme that makes tryptophan -> KYN (too much KYN)

include serotonin AND melatonin et al.

Eliminate one substrate...melatonin via "light" and up goes tryptophan -> protective serotonin.

" Direct evidence has also been provided that serotonin is capable of releasing acetylcholine from the Auerbach plexus.

It is very likely that serotonin stimulates ganglion cells, which in fact leads to firing and, consequently, to an increase of acetylcholine release from the nerve terminals."

http://www.ncbi.nlm.nih.gov/pubmed/650204


There are a LOT more benefits to HBOT which I will post later with links.

Posts: 9481 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
Monti
LymeNet Contributor
Member # 45718

Icon 1 posted      Profile for Monti     Send New Private Message       Edit/Delete Post   Reply With Quote 
Purple haze...

Your dreaming experience is the exact same as mine. I also often wonder where my dreams will take me.

I would say that ever since in contracted Lyme my dreaming has intensified. But no noticeable change since using mhbot.

Posts: 120 | From Maine | Registered: May 2015  |  IP: Logged | Report this post to a Moderator
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
Thanks for the input...y'all. I found all posts fascinating! Phoiph, that is so interesting that you had weird head "phases" because I do feel like something is happening upstairs, just not sure if it is for the better yet or not!

I wonder if I dream more because I normally dive before bedtime? When do the rest of you dive?

Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
Monti
LymeNet Contributor
Member # 45718

Icon 1 posted      Profile for Monti     Send New Private Message       Edit/Delete Post   Reply With Quote 
I dive around 4:30pm each day
Posts: 120 | From Maine | Registered: May 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
foxy loxy...

I realize you are just beginning mHBOT...but am wondering if the quality of your sleep has changed (for better or worse)?

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
Jolley
Member
Member # 46454

Icon 1 posted      Profile for Jolley     Send New Private Message       Edit/Delete Post   Reply With Quote 
I've been watching this thread for awhile and will be starting mhbot in January; thank you for sharing your journeys. I just bought my oxygen concentrator and have been using it daily. Excited to begin.
Posts: 64 | From Washington | Registered: Aug 2015  |  IP: Logged | Report this post to a Moderator
foxy loxy
LymeNet Contributor
Member # 47053

Icon 1 posted      Profile for foxy loxy     Send New Private Message       Edit/Delete Post   Reply With Quote 
Phoiph, I would say I am not sleeping with such a "dead" sort of sleep, I used to have... but I am not having trouble sleeping.

Since becoming sick I go to sleep... BOOM!! Fast! now with mHBOT I dream... one thing after the next in almost A.D.D fashion!

I would say mHBOT makes me sleepy/tired. That is why I do it before bedtime.

Welcome Jolley! We do have quite the diving group! I hope mHBOT helps you! [Smile]

Posts: 477 | From Pennsylvania | Registered: Nov 2015  |  IP: Logged | Report this post to a Moderator
Marnie
Frequent Contributor (5K+ posts)
Member # 773

Icon 1 posted      Profile for Marnie     Send New Private Message       Edit/Delete Post   Reply With Quote 
I hope this has not already been posted:

"Lyme disease is the most commonly reported vector-borne illness in the United States, but it is relatively rare in Taiwan.

Lyme disease can be treated with antibiotic agents, but approximately 20% of these patients experience persistent or intermittent subjective symptoms, so-called chronic Lyme disease (CLD).

The mechanisms of CLD remain unclear and the symptoms related to CLD are difficult to manage.

Hyperbaric oxygen therapy (HBOT) was applied in CLD therapy in the 1990s. However, reported information regarding the effectiveness of HBOT for CLD is still limited.

Here, we present a patient with CLD who was successfully treated with HBOT."

I can't post link because of ( ) in the link. See if you can find it using words in the quote above.

Does HBOT "compete" with Bb's nitrite reductase -> toxic NO (to Bb) versus Bb using nitrite reductase -> nitrate (Doxy inhibits!)-> ammonia?

Deoxyhemoglobin triggers

nitrite reduction to nitric oxide normally, but Bb "steals" and uses nitrite.

Cytochrome c nitrite reductase is a bacterial enzyme that catalyzes the six electron reduction of nitrite to ammonia; an important step in the biological nitrogen cycle.

The enzyme catalyses the second step in the
two step conversion of nitrate to ammonia, which

allows certain bacteria to use nitrite as a terminal electron acceptor, rather than oxygen, during anaerobic conditions.

Wikipedia


Bb - NapA

Transcripts of genes that encode proteins containing iron-sulfur clusters or iron, including NapA (nitrite reductase)

http://webcache.googleusercontent.com/search?q=cache:6YY7Hp-BhZUJ:http://www.biomedcentral.com/1471-2164/10/481

Copper and iron are involved.

Collectively, these data strongly support a central role of ***NapA in promoting both Treg response and immune suppression in the CSF of patients with chronic Lyme borreliosis***

and suggest that NapA and the Treg pathway may represent novel therapeutic targets for the prevention and treatment of the disease.

http://www.ncbi.nlm.nih.gov/pubmed/24355226

Treg = T regulatory cells. Often high, but not always!

Tregs were depleted by ***PC61 antibody*** in nephrotic mice treated with M(2a) or M(2c).
(Treg = T regulatory)

http://www.ncbi.nlm.nih.gov/pubmed/23636175 2013

PC61 mAb (anti-murine CD25 rat IgG1).

Treg depletion diminished the superior effects of M(2c) compared to M(2a) in protection against renal injury, inflammatory infiltrates, and renal fibrosis. Thus, M(2c) are more potent than M(2a) macrophages in protecting against renal injury due to their ability to induce Tregs.

http://www.ncbi.nlm.nih.gov/pubmed/23636175 2013


M2a and M2c are upregulated via HBOT.

In Lupus,

Further, apparently *reduced populations of M2a and M2c* subtype macrophages may contribute to the lack of anti-inflammatory activity apparent in the disease.

M2b subtype macrophages may actually have a role in causing disease directly.

http://webcache.googleusercontent.com/search?q=cache:XfwYFNHWmnUJ:http://www.discoverymedicine.com/Jacob-Orme/2012/02/23/macrophage-subpopulations-in-systemic-lupus-erythematosus/

HBO upregulates IL4 & IL-10 (M2a and M2c respectively) and - immune response anti-inflammatory

which down-regulates pro-inflammatory species IL-1β, IL-2, IL-6, tumor necrosis factor-α, interferon-γ (M1), matrix metalloproteinase-9, nitric oxide synthase, myeloperoxidase, and reactive oxygen species.

http://www.hypermed.com.au/Clinical%20Research/Spinal%20Cord%20Injury%20Hyperbaric%20Oxygenation.htm

Colorful picture here to compare the above quote with:

http://brainimmune.com/stress-induced-%CE%B22-adrenoceptor-mediated-m2-macrophage-polarization-promoting-tumor-growth-in-a-mouse-model-of-breast-cancer/

To "see" where HBOT is working...what it promotes and what it inhibits.

Posts: 9481 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
Koco800
Member
Member # 47160

Icon 1 posted      Profile for Koco800   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hey all,

I am starting mild hyperbaric therapy. I got Lyme, Bartonella, Babesia, and who knows what else in 2004. I've seen a few LLMDs, but have never gotten totally well. I've tried a lot of antibiotics and other therapies. I got a prescription from my LLMD for a portable home chamber and oxygen concentrator. I'm about a week in, every other day for about 45-50 minutes (trying to take it slow). I may build up to an hour every day. Not much to report so far, but I plan to continue. I'm also still on antibiotics and malarone. I finally learned how to zip the chamber myself, which will make self-treatment easier (it's still pretty hard to zip all the zippers though).

--------------------
.

Posts: 15 | From New York | Registered: Dec 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Welcome, Koco800...

What kind of chamber and oxygen concentrator did you purchase?

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
Peimomma
LymeNet Contributor
Member # 45177

Icon 1 posted      Profile for Peimomma     Send New Private Message       Edit/Delete Post   Reply With Quote 
Welcome to all the Newbies😊

So encouraging to see new posts, experiences and gains.

367 dives to date and today I submitted a resume for a part time job👍. I'm in no hurry and causally looking, mostly word of mouth for now.

Posts: 238 | From AZ | Registered: Jan 2015  |  IP: Logged | Report this post to a Moderator
Haley
Frequent Contributor (1K+ posts)
Member # 22008

Icon 1 posted      Profile for Haley     Send New Private Message       Edit/Delete Post   Reply With Quote 
Welcome koko800. I remember being completly exhausted after zipping myself in. These days when I get down about my health , I get in my chamber and I realize how exhausting it was just to get in. I then stop take a breath and realize I AM making progress. I have not been exhausted from getting in the chamber for a long time. Sometimes the changes are very subtle!
Posts: 2232 | From USA | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
Haley
Frequent Contributor (1K+ posts)
Member # 22008

Icon 1 posted      Profile for Haley     Send New Private Message       Edit/Delete Post   Reply With Quote 
I would like to buy a regulator for my oxygen tank and try to put that through my chamber. Any ideas? What type of regulator do I get. I think the pure oxygen would increase the efficacy.
Posts: 2232 | From USA | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
Koco800
Member
Member # 47160

Icon 1 posted      Profile for Koco800   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
Thanks for the replies! I am using the Newtowne 24'' chamber and an Airsep Intensity concentrator...

--------------------
.

Posts: 15 | From New York | Registered: Dec 2015  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi Haley...

I'm sure this is possible using an 02 tank, but my concern would be that it may raise the ambient oxygen level inside the chamber enough for there to be greater risk of fire.

In commercial chambers where 100% medical grade oxygen is breathed through a mask (even when the chamber is pressurized with room air), there are restrictions...(e.g., no synthetic clothing, electronics, newspaper, perfumes/hairspray, jewelry, etc.)

I will ask Oxyhealth about it...

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Koco800...

An important FYI...

You may already be aware of this, but if you have the AirSep "New Life Intensity" 10 LPM, 20 PSI, you should set it at no more than 8.5 LPM when used with the chamber.

(For explanation, refer to the 2nd post on this page...)

Also...very important to always have your concentrator ON whenever there is pressure in the chamber...otherwise, the backpressure from the chamber will damage it.

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
S13
LymeNet Contributor
Member # 42830

Icon 1 posted      Profile for S13     Send New Private Message       Edit/Delete Post   Reply With Quote 
I just set it at 10 LPM and it works fine.

I dont know if american Airseps are different, but my Intensity does not have an on demand feature, so it works continuously up to 10 LPM without problems.

Posts: 387 | From The Netherlands | Registered: Nov 2013  |  IP: Logged | Report this post to a Moderator
Phoiph
Frequent Contributor (1K+ posts)
Member # 41238

Icon 1 posted      Profile for Phoiph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi S13...

It may seem to be working fine (and may very well be), but setting the AirSep at 10 while using it with a chamber will shorten the life of the unit.

It is a great unit (the best, in my opinion), but these concentrators were not made to be used with chambers...so running it at 10 combined with the backpressure of the chamber is overworking it.

You may not even know it is going into a pulse/on demand mode to conserve oxygen purity. The technicians might not even tell you that, but the engineers will.

It is unlikely anyone who is resting/laying down in the chamber would breathe 10LPM anyway...so 8 to 8.5 is a better setting that won't sacrifice 02 purity, and will extend the life of your concentrator.

By the way, does your AirSep have a small yellow light (02 monitor/alarm feature) which lights up when you turn it on?

Posts: 2079 | From Earth | Registered: Jul 2013  |  IP: Logged | Report this post to a Moderator
  This topic comprises 91 pages: 1  2  3  ...  17  18  19  20  21  22  23  ...  89  90  91   

Quick Reply
Message:

HTML is not enabled.
UBB Code� is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.